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4f7m

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[[Image:4f7m.png|left|200px]]
 
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{{STRUCTURE_4f7m| PDB=4f7m | SCENE= }}
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==Crystal Structure of HLA-A*2402 Complexed with a Newly Identified Peptide from 2009 H1N1 PA (649-658)==
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<StructureSection load='4f7m' size='340' side='right'caption='[[4f7m]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4f7m]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Influenza_A_virus_H3N2 Influenza A virus H3N2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F7M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4F7M FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4f7m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4f7m OCA], [https://pdbe.org/4f7m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4f7m RCSB], [https://www.ebi.ac.uk/pdbsum/4f7m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4f7m ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[https://omim.org/entry/241600 241600]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
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===Crystal Structure of HLA-A*2402 Complexed with a Newly Identified Peptide from 2009 H1N1 PA (649-658)===
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==See Also==
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*[[Beta-2 microglobulin 3D structures|Beta-2 microglobulin 3D structures]]
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{{ABSTRACT_PUBMED_23015716}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[4f7m]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F7M OCA].
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: George, F G.]]
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[[Category: Influenza A virus H3N2]]
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[[Category: Liu, J.]]
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[[Category: Large Structures]]
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[[Category: Qi, J.]]
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[[Category: George FG]]
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[[Category: Tan, S.]]
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[[Category: Liu J]]
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[[Category: Wang, H.]]
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[[Category: Qi J]]
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[[Category: Wu, B.]]
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[[Category: Tan S]]
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[[Category: Yi, Y.]]
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[[Category: Wang H]]
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[[Category: Zhang, S.]]
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[[Category: Wu B]]
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[[Category: Zhu, F.]]
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[[Category: Yi Y]]
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[[Category: 2009 h1n1]]
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[[Category: Zhang S]]
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[[Category: Hla-a*2402]]
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[[Category: Zhu F]]
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[[Category: Hla-a3 supertype]]
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[[Category: Immune system]]
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[[Category: Influenza a virus]]
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Current revision

Crystal Structure of HLA-A*2402 Complexed with a Newly Identified Peptide from 2009 H1N1 PA (649-658)

PDB ID 4f7m

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