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4f9l

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{{STRUCTURE_4f9l| PDB=4f9l | SCENE= }}
 
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===Crystal Structure of the Human BTN3A1 Ectodomain in Complex with the 20.1 Single Chain Antibody===
 
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{{ABSTRACT_PUBMED_22846996}}
 
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==Function==
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==Crystal Structure of the Human BTN3A1 Ectodomain in Complex with the 20.1 Single Chain Antibody==
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[[http://www.uniprot.org/uniprot/BT3A1_HUMAN BT3A1_HUMAN]] Plays a role in T-cell activation and in the adaptive immune response. Regulates the proliferation of activated T-cells. Regulates the release of cytokines and IFNG by activated T-cells. Mediates the response of T-cells toward infected and transformed cells that are characterized by high levels of phosphorylated metabolites, such as isopentenyl pyrophosphate.<ref>PMID:21113407</ref> <ref>PMID:21918970</ref> <ref>PMID:22767497</ref> <ref>PMID:22846996</ref>
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<StructureSection load='4f9l' size='340' side='right'caption='[[4f9l]], [[Resolution|resolution]] 3.14&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4f9l]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F9L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4F9L FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1404&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4f9l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4f9l OCA], [https://pdbe.org/4f9l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4f9l RCSB], [https://www.ebi.ac.uk/pdbsum/4f9l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4f9l ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/BT3A1_HUMAN BT3A1_HUMAN] Plays a role in T-cell activation and in the adaptive immune response. Regulates the proliferation of activated T-cells. Regulates the release of cytokines and IFNG by activated T-cells. Mediates the response of T-cells toward infected and transformed cells that are characterized by high levels of phosphorylated metabolites, such as isopentenyl pyrophosphate.<ref>PMID:21113407</ref> <ref>PMID:21918970</ref> <ref>PMID:22767497</ref> <ref>PMID:22846996</ref>
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==About this Structure==
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==See Also==
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[[4f9l]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F9L OCA].
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*[[Antibody 3D structures|Antibody 3D structures]]
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*[[Monoclonal Antibodies 3D structures|Monoclonal Antibodies 3D structures]]
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==Reference==
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*[[3D structures of non-human antibody|3D structures of non-human antibody]]
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<ref group="xtra">PMID:022846996</ref><references group="xtra"/><references/>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Adams, E J.]]
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[[Category: Adams EJ]]
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[[Category: Bonneville, M.]]
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[[Category: Bonneville M]]
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[[Category: Harly, C.]]
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[[Category: Harly C]]
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[[Category: Nedellec, S.]]
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[[Category: Nedellec S]]
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[[Category: Olive, D.]]
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[[Category: Olive D]]
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[[Category: Palakodeti, A.]]
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[[Category: Palakodeti A]]
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[[Category: Sandstrom, A.]]
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[[Category: Sandstrom A]]
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[[Category: Scotet, E.]]
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[[Category: Scotet E]]
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[[Category: Sundaresan, L.]]
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[[Category: Sundaresan L]]
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[[Category: B7 superfamily]]
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[[Category: Butyrophilin]]
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[[Category: Cd277]]
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[[Category: Immune system]]
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Current revision

Crystal Structure of the Human BTN3A1 Ectodomain in Complex with the 20.1 Single Chain Antibody

PDB ID 4f9l

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