This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


4fal

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (15:20, 14 March 2024) (edit) (undo)
 
(3 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:4fal.jpg|left|200px]]
 
-
{{STRUCTURE_4fal| PDB=4fal | SCENE= }}
+
==Crystal structure of human 17beta-hydroxysteroid dehydrogenase type 5 in complex with 3-((3,4-dihydroisoquinolin-2(1H)-yl)sulfonyl)-N-methylbenzamide (80)==
 +
<StructureSection load='4fal' size='340' side='right'caption='[[4fal]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[4fal]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FAL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FAL FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0T0:3-(3,4-DIHYDROISOQUINOLIN-2(1H)-YLSULFONYL)-N-METHYLBENZAMIDE'>0T0</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fal FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fal OCA], [https://pdbe.org/4fal PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fal RCSB], [https://www.ebi.ac.uk/pdbsum/4fal PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fal ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/AK1C3_HUMAN AK1C3_HUMAN] Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone.
-
===Crystal structure of human 17beta-hydroxysteroid dehydrogenase type 5 in complex with 3-((3,4-dihydroisoquinolin-2(1H)-yl)sulfonyl)-N-methylbenzamide (80)===
+
==See Also==
-
 
+
*[[Prostaglandin F synthase 3D structures|Prostaglandin F synthase 3D structures]]
-
{{ABSTRACT_PUBMED_22877157}}
+
__TOC__
-
 
+
</StructureSection>
-
==About this Structure==
+
[[Category: Homo sapiens]]
-
[[4fal]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FAL OCA].
+
[[Category: Large Structures]]
-
[[Category: Atwell, G J.]]
+
[[Category: Atwell GJ]]
-
[[Category: Brooke, D G.]]
+
[[Category: Brooke DG]]
-
[[Category: Denny, W A.]]
+
[[Category: Denny WA]]
-
[[Category: Flanagan, J U.]]
+
[[Category: Flanagan JU]]
-
[[Category: Hamilton, E J.]]
+
[[Category: Hamilton EJ]]
-
[[Category: Heinrich, D.]]
+
[[Category: Heinrich D]]
-
[[Category: Jamieson, S M.F.]]
+
[[Category: Jamieson SMF]]
-
[[Category: Owen, P J.]]
+
[[Category: Owen PJ]]
-
[[Category: Raynham, T.]]
+
[[Category: Raynham T]]
-
[[Category: Rigoreau, L J.M.]]
+
[[Category: Rigoreau LJM]]
-
[[Category: Samlal, S S.]]
+
[[Category: Samlal SS]]
-
[[Category: Schroeder, E.]]
+
[[Category: Schroeder E]]
-
[[Category: Silva, S.]]
+
[[Category: Silva S]]
-
[[Category: Soudy, C.]]
+
[[Category: Soudy C]]
-
[[Category: Trivier, E.]]
+
[[Category: Trivier E]]
-
[[Category: Turnbull, A P.]]
+
[[Category: Turnbull AP]]
-
[[Category: Aldo-keto reductase]]
+
-
[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
+

Current revision

Crystal structure of human 17beta-hydroxysteroid dehydrogenase type 5 in complex with 3-((3,4-dihydroisoquinolin-2(1H)-yl)sulfonyl)-N-methylbenzamide (80)

PDB ID 4fal

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4fal"
Personal tools