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4fk6

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[[Image:4fk6.jpg|left|200px]]
 
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{{STRUCTURE_4fk6| PDB=4fk6 | SCENE= }}
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==JAK1 kinase (JH1 domain) in complex with compound 72==
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<StructureSection load='4fk6' size='340' side='right'caption='[[4fk6]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4fk6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FK6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FK6 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0UJ:N-({1-[(1R,2R,4S)-BICYCLO[2.2.1]HEPT-2-YL]-1,6-DIHYDROIMIDAZO[4,5-D]PYRROLO[2,3-B]PYRIDIN-2-YL}METHYL)METHANESULFONAMIDE'>0UJ</scene>, <scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fk6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fk6 OCA], [https://pdbe.org/4fk6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fk6 RCSB], [https://www.ebi.ac.uk/pdbsum/4fk6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fk6 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/JAK1_HUMAN JAK1_HUMAN] Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor.
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===JAK1 kinase (JH1 domain) in complex with compound 72===
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==See Also==
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*[[Janus kinase 3D structures|Janus kinase 3D structures]]
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__TOC__
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==About this Structure==
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</StructureSection>
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[[4fk6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FK6 OCA].
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Non-specific protein-tyrosine kinase]]
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[[Category: Large Structures]]
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[[Category: Eigenbrot, C.]]
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[[Category: Eigenbrot C]]
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[[Category: Steffek, M.]]
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[[Category: Steffek M]]
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[[Category: Phospho transfer]]
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[[Category: Phospho tyrosine]]
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[[Category: Protein kinase]]
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[[Category: Transferase-transferase inhibitor complex]]
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Current revision

JAK1 kinase (JH1 domain) in complex with compound 72

PDB ID 4fk6

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