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4fm5
From Proteopedia
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| - | [[Image:4fm5.jpg|left|200px]] | ||
| - | + | ==X-ray structure of des-methylflurbiprofen bound to murine COX-2== | |
| + | <StructureSection load='4fm5' size='340' side='right'caption='[[4fm5]], [[Resolution|resolution]] 2.81Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4fm5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FM5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FM5 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.81Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=DF0:(2-FLUOROBIPHENYL-4-YL)ACETIC+ACID'>DF0</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fm5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fm5 OCA], [https://pdbe.org/4fm5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fm5 RCSB], [https://www.ebi.ac.uk/pdbsum/4fm5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fm5 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PGH2_MOUSE PGH2_MOUSE] Mediates the formation of prostaglandins from arachidonate. May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity.<ref>PMID:12925531</ref> <ref>PMID:20463020</ref> <ref>PMID:20810665</ref> <ref>PMID:21489986</ref> | ||
| - | == | + | ==See Also== |
| - | + | *[[Cyclooxygenase 3D structures|Cyclooxygenase 3D structures]] | |
| - | + | == References == | |
| - | == | + | <references/> |
| - | [[ | + | __TOC__ |
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
| - | + | [[Category: Banerjee S]] | |
| - | [[Category: Banerjee | + | [[Category: Marnett LJ]] |
| - | [[Category: Marnett | + | [[Category: Windsor MA]] |
| - | [[Category: Windsor | + | [[Category: Xu S]] |
| - | [[Category: Xu | + | |
| - | + | ||
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Current revision
X-ray structure of des-methylflurbiprofen bound to murine COX-2
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