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4fmu
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 4fmu is ON HOLD Authors: Dong, A., Zeng, H., Ibez, G., Zheng, W., Tempel, W., Bountra, C., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Brown, P.J....) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of Methyltransferase domain of human SET domain-containing protein 2 Compound: Pr-SNF== | |
| + | <StructureSection load='4fmu' size='340' side='right'caption='[[4fmu]], [[Resolution|resolution]] 2.10Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4fmu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FMU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FMU FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0UM:(2S,5S)-2-AMINO-6-[(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]-5-(PROPYLAMINO)HEXANOIC+ACID'>0UM</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fmu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fmu OCA], [https://pdbe.org/4fmu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fmu RCSB], [https://www.ebi.ac.uk/pdbsum/4fmu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fmu ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/SETD2_HUMAN SETD2_HUMAN] Histone methyltransferase that methylates 'Lys-36' of histone H3. H3 'Lys-36' methylation represents a specific tag for epigenetic transcriptional activation. Probably plays a role in chromatin structure modulation during elongation via its interaction with hyperphosphorylated POLR2A. Binds DNA at promoters. May also act as a transcription activator that binds to promoters. Binds to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression.<ref>PMID:16118227</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Histone methyltransferase 3D structures|Histone methyltransferase 3D structures]] | |
| - | + | == References == | |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Arrowsmith CH]] | ||
| + | [[Category: Bountra C]] | ||
| + | [[Category: Brown PJ]] | ||
| + | [[Category: Dong A]] | ||
| + | [[Category: Edwards AM]] | ||
| + | [[Category: Ibanez G]] | ||
| + | [[Category: Luo M]] | ||
| + | [[Category: Min J]] | ||
| + | [[Category: Tempel W]] | ||
| + | [[Category: Wu H]] | ||
| + | [[Category: Zeng H]] | ||
| + | [[Category: Zheng W]] | ||
Current revision
Crystal structure of Methyltransferase domain of human SET domain-containing protein 2 Compound: Pr-SNF
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Categories: Homo sapiens | Large Structures | Arrowsmith CH | Bountra C | Brown PJ | Dong A | Edwards AM | Ibanez G | Luo M | Min J | Tempel W | Wu H | Zeng H | Zheng W
