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4fnh
From Proteopedia
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| - | [[Image:4fnh.png|left|200px]] | ||
| - | + | ==Crystal structure of IsdI-W66Y in complex with heme== | |
| - | + | <StructureSection load='4fnh' size='340' side='right'caption='[[4fnh]], [[Resolution|resolution]] 1.90Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4fnh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_N315 Staphylococcus aureus subsp. aureus N315]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FNH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FNH FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr> | |
| - | == | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fnh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fnh OCA], [https://pdbe.org/4fnh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fnh RCSB], [https://www.ebi.ac.uk/pdbsum/4fnh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fnh ProSAT]</span></td></tr> |
| - | [[4fnh]] is a 2 chain structure with sequence from [ | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/HDOX2_STAAN HDOX2_STAAN] Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta-bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron.[HAMAP-Rule:MF_01272]<ref>PMID:18713745</ref> <ref>PMID:20180905</ref> | ||
==See Also== | ==See Also== | ||
| - | *[[Heme oxygenase|Heme oxygenase]] | + | *[[Heme oxygenase 3D structures|Heme oxygenase 3D structures]] |
| - | [[Category: | + | *[[Monooxygenase 3D structures|Monooxygenase 3D structures]] |
| - | [[Category: Staphylococcus aureus subsp. aureus | + | == References == |
| - | [[Category: Murphy | + | <references/> |
| - | [[Category: Ukpabi | + | __TOC__ |
| - | + | </StructureSection> | |
| - | + | [[Category: Large Structures]] | |
| + | [[Category: Staphylococcus aureus subsp. aureus N315]] | ||
| + | [[Category: Murphy MEP]] | ||
| + | [[Category: Ukpabi GN]] | ||
Current revision
Crystal structure of IsdI-W66Y in complex with heme
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