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4fnk
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 4fnk is ON HOLD Authors: Ekiert, D.C., Wilson, I.A. Description: Crystal structure of the A/Hong Kong/1/1968 (H3N2) influenza virus hemagglutinin) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the A/Hong Kong/1/1968 (H3N2) influenza virus hemagglutinin== | |
| + | <StructureSection load='4fnk' size='340' side='right'caption='[[4fnk]], [[Resolution|resolution]] 1.90Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4fnk]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/Hong_Kong/1/1968(H3N2)) Influenza A virus (A/Hong Kong/1/1968(H3N2))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FNK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FNK FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.901Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fnk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fnk OCA], [https://pdbe.org/4fnk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fnk RCSB], [https://www.ebi.ac.uk/pdbsum/4fnk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fnk ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/HEMA_I68A4 HEMA_I68A4] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity). | ||
| - | + | ==See Also== | |
| - | + | *[[Hemagglutinin 3D structures|Hemagglutinin 3D structures]] | |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Ekiert DC]] | ||
| + | [[Category: Wilson IA]] | ||
Current revision
Crystal structure of the A/Hong Kong/1/1968 (H3N2) influenza virus hemagglutinin
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