4fom
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of human nectin-3 full ectodomain (D1-D3)== | |
| + | <StructureSection load='4fom' size='340' side='right'caption='[[4fom]], [[Resolution|resolution]] 3.93Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4fom]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FOM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FOM FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.93Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fom FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fom OCA], [https://pdbe.org/4fom PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fom RCSB], [https://www.ebi.ac.uk/pdbsum/4fom PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fom ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/NECT3_HUMAN NECT3_HUMAN] Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with NECTIN2 at Sertoli-spermatid junctions. Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. Plays a role in the morphology of the ciliary body.<ref>PMID:16216929</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Poliovirus receptor-related protein|Poliovirus receptor-related protein]] | |
| - | + | == References == | |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Brasch J]] | ||
| + | [[Category: Harrison OJ]] | ||
| + | [[Category: Jin X]] | ||
| + | [[Category: Shapiro L]] | ||
Current revision
Crystal structure of human nectin-3 full ectodomain (D1-D3)
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