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4g83
From Proteopedia
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==Crystal Structure of p73 DNA-Binding Domain Tetramer bound to a Full Response-Element== | ==Crystal Structure of p73 DNA-Binding Domain Tetramer bound to a Full Response-Element== | ||
| - | <StructureSection load='4g83' size='340' side='right' caption='[[4g83]], [[Resolution|resolution]] 4.00Å' scene=''> | + | <StructureSection load='4g83' size='340' side='right'caption='[[4g83]], [[Resolution|resolution]] 4.00Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4g83]] is a 4 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[4g83]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G83 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4G83 FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 4Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | <tr id=' | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4g83 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g83 OCA], [https://pdbe.org/4g83 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4g83 RCSB], [https://www.ebi.ac.uk/pdbsum/4g83 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4g83 ProSAT]</span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/P73_HUMAN P73_HUMAN] Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.<ref>PMID:11753569</ref> <ref>PMID:10203277</ref> <ref>PMID:18174154</ref> |
==See Also== | ==See Also== | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Ethayathulla AS]] |
| - | [[Category: | + | [[Category: Viadiu H]] |
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Current revision
Crystal Structure of p73 DNA-Binding Domain Tetramer bound to a Full Response-Element
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