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4g84

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[[Image:4g84.jpg|left|200px]]
 
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{{STRUCTURE_4g84| PDB=4g84 | SCENE= }}
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==Crystal structure of human HisRS==
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<StructureSection load='4g84' size='340' side='right'caption='[[4g84]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4g84]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G84 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4G84 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4g84 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g84 OCA], [https://pdbe.org/4g84 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4g84 RCSB], [https://www.ebi.ac.uk/pdbsum/4g84 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4g84 ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/HARS1_HUMAN HARS1_HUMAN] Usher syndrome type 3;Autosomal dominant Charcot-Marie-Tooth disease type 2W. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/HARS1_HUMAN HARS1_HUMAN] Catalyzes the ATP-dependent ligation of histidine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (His-AMP) (PubMed:29235198). Plays a role in axon guidance (PubMed:26072516).<ref>PMID:26072516</ref> <ref>PMID:29235198</ref>
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===Crystal structure of human HisRS===
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==See Also==
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*[[Aminoacyl tRNA synthetase 3D structures|Aminoacyl tRNA synthetase 3D structures]]
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{{ABSTRACT_PUBMED_22958643}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[4g84]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G84 OCA].
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</StructureSection>
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[[Category: Histidine--tRNA ligase]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Schimmel, P.]]
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[[Category: Large Structures]]
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[[Category: Wei, Z.]]
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[[Category: Schimmel P]]
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[[Category: Wu, J.]]
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[[Category: Wei Z]]
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[[Category: Yang, X L.]]
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[[Category: Wu J]]
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[[Category: Zhang, M.]]
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[[Category: Yang X-L]]
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[[Category: Zhou, J J.]]
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[[Category: Zhang M]]
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[[Category: Ligase]]
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[[Category: Zhou JJ]]
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[[Category: Synthetase]]
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Current revision

Crystal structure of human HisRS

PDB ID 4g84

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