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4g8m

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[[Image:4g8m.jpg|left|200px]]
 
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{{STRUCTURE_4g8m| PDB=4g8m | SCENE= }}
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==Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with the agonist CBG-IV at 2.05A resolution==
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<StructureSection load='4g8m' size='340' side='right'caption='[[4g8m]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4g8m]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G8M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4G8M FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=G8M:(1S,2R)-2-[(S)-AMINO(CARBOXY)METHYL]CYCLOBUTANECARBOXYLIC+ACID'>G8M</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4g8m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g8m OCA], [https://pdbe.org/4g8m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4g8m RCSB], [https://www.ebi.ac.uk/pdbsum/4g8m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4g8m ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GRIA2_RAT GRIA2_RAT] Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.<ref>PMID:9351977</ref> <ref>PMID:19265014</ref> <ref>PMID:21172611</ref> <ref>PMID:12501192</ref> <ref>PMID:12015593</ref> <ref>PMID:12872125</ref> <ref>PMID:12730367</ref> <ref>PMID:16192394</ref> <ref>PMID:15591246</ref> <ref>PMID:17018279</ref> <ref>PMID:16483599</ref> <ref>PMID:19946266</ref> <ref>PMID:21317873</ref> <ref>PMID:21846932</ref>
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===Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with the agonist CBG-IV at 2.05A resolution===
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==See Also==
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*[[Glutamate receptor 3D structures|Glutamate receptor 3D structures]]
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{{ABSTRACT_PUBMED_22789682}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[4g8m]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G8M OCA].
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</StructureSection>
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[[Category: Large Structures]]
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==Reference==
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<ref group="xtra">PMID:022789682</ref><references group="xtra"/>
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[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Frydenvang, K.]]
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[[Category: Frydenvang K]]
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[[Category: Gajhede, M.]]
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[[Category: Gajhede M]]
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[[Category: Juknaite, L.]]
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[[Category: Juknaite L]]
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[[Category: Kastrup, J S.]]
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[[Category: Kastrup JS]]
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[[Category: Agonist]]
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[[Category: Ampa receptor ligand-binding domain]]
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[[Category: Glur2-s1s2j]]
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[[Category: Membrane protein]]
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[[Category: Membrane protein-agonist complex]]
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Current revision

Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with the agonist CBG-IV at 2.05A resolution

PDB ID 4g8m

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