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4g8n
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the kainate receptor GluK3 ligand-binding domain in complex with the agonist G8M== | |
| + | <StructureSection load='4g8n' size='340' side='right'caption='[[4g8n]], [[Resolution|resolution]] 2.30Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4g8n]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G8N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4G8N FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=G8M:(1S,2R)-2-[(S)-AMINO(CARBOXY)METHYL]CYCLOBUTANECARBOXYLIC+ACID'>G8M</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4g8n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g8n OCA], [https://pdbe.org/4g8n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4g8n RCSB], [https://www.ebi.ac.uk/pdbsum/4g8n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4g8n ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/GRIK3_RAT GRIK3_RAT] Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds domoate > kainate >> L-glutamate = quisqualate >> AMPA = NMDA.<ref>PMID:21907808</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Glutamate receptor 3D structures|Glutamate receptor 3D structures]] | |
| - | + | == References == | |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Rattus norvegicus]] | ||
| + | [[Category: Frydenvang K]] | ||
| + | [[Category: Gajhede M]] | ||
| + | [[Category: Kastrup JS]] | ||
| + | [[Category: Venskutonyte R]] | ||
Current revision
Crystal structure of the kainate receptor GluK3 ligand-binding domain in complex with the agonist G8M
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