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4gc9
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of murine TFB1M in complex with SAM== | |
| - | + | <StructureSection load='4gc9' size='340' side='right'caption='[[4gc9]], [[Resolution|resolution]] 2.10Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4gc9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GC9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GC9 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.103Å</td></tr> | |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gc9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gc9 OCA], [https://pdbe.org/4gc9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gc9 RCSB], [https://www.ebi.ac.uk/pdbsum/4gc9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gc9 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/TFB1M_MOUSE TFB1M_MOUSE] S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity (By similarity). | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mus musculus]] | ||
| + | [[Category: Garcia-Diaz M]] | ||
| + | [[Category: Guja KE]] | ||
| + | [[Category: Hambardjieva E]] | ||
| + | [[Category: Karzai AW]] | ||
| + | [[Category: Mejia E]] | ||
| + | [[Category: Shi H]] | ||
| + | [[Category: Venkataraman K]] | ||
| + | [[Category: Yakubovskaya E]] | ||
Current revision
Crystal structure of murine TFB1M in complex with SAM
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