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4ggb
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 4ggb is ON HOLD Authors: Vetting, M.W., Bouvier, J.T., Morisco, L.L., Wasserman, S.R., Sojitra, S., Imker, H.J., Gerlt, J.A., Almo, S.C., Enzyme Fun...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of a proposed galactarolactone cycloisomerase from agrobacterium tumefaciens, TARGET EFI-500704, WITH BOUND CA, DISORDERED LOOPS== | |
| - | + | <StructureSection load='4ggb' size='340' side='right'caption='[[4ggb]], [[Resolution|resolution]] 2.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4ggb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Agrobacterium_fabrum_str._C58 Agrobacterium fabrum str. C58]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GGB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GGB FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ggb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ggb OCA], [https://pdbe.org/4ggb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ggb RCSB], [https://www.ebi.ac.uk/pdbsum/4ggb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ggb ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/GCI_AGRFC GCI_AGRFC] Catalyzes the ring opening of D-galactaro-1,4-lactone to yield 5-keto-4-deoxy-D-glucarate (KDG) via a beta-elimination reaction. This is a step in the oxidative degradation pathway of D-galacturonate, which allows A.tumefaciens to utilize D-galacturonate as a sole carbon source. To a lesser extent, can also use D-glucaro-1,4-lactone as substrate to produce KDG, but cannot use D-galactaro-1,5-lactone, D-glucaro-6,3-lactone and linear D-glucarate.<ref>PMID:22493433</ref> <ref>PMID:24450804</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Agrobacterium fabrum str. C58]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Almo SC]] | ||
| + | [[Category: Bouvier JT]] | ||
| + | [[Category: Gerlt JA]] | ||
| + | [[Category: Imker HJ]] | ||
| + | [[Category: Morisco LL]] | ||
| + | [[Category: Sojitra S]] | ||
| + | [[Category: Vetting MW]] | ||
| + | [[Category: Wasserman SR]] | ||
Current revision
Crystal structure of a proposed galactarolactone cycloisomerase from agrobacterium tumefaciens, TARGET EFI-500704, WITH BOUND CA, DISORDERED LOOPS
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