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4gm3

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(New page: '''Unreleased structure''' The entry 4gm3 is ON HOLD Authors: Karatas, H., Townsend, E. C., Chen, Y., Bernard, D., Cao, F., Liu, L., Lei, M., Dou, Y., Wang, S. Description: Crystal str...)
Current revision (15:50, 14 March 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 4gm3 is ON HOLD
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==Crystal structure of human WD repeat domain 5 with compound MM-101==
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<StructureSection load='4gm3' size='340' side='right'caption='[[4gm3]], [[Resolution|resolution]] 3.39&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4gm3]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GM3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GM3 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.393&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0XL:2-AMINO-2-ETHYLBUTANOIC+ACID'>0XL</scene>, <scene name='pdbligand=0XM:1,1-DIPHENYLMETHANAMINE'>0XM</scene>, <scene name='pdbligand=AC5:1-AMINOCYCLOPENTANECARBOXYLIC+ACID'>AC5</scene>, <scene name='pdbligand=ALQ:2-METHYL-PROPIONIC+ACID'>ALQ</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gm3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gm3 OCA], [https://pdbe.org/4gm3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gm3 RCSB], [https://www.ebi.ac.uk/pdbsum/4gm3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gm3 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/WDR5_HUMAN WDR5_HUMAN] Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation.<ref>PMID:19556245</ref> <ref>PMID:19103755</ref> <ref>PMID:20018852</ref> <ref>PMID:16600877</ref> <ref>PMID:16829960</ref>
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Authors: Karatas, H., Townsend, E. C., Chen, Y., Bernard, D., Cao, F., Liu, L., Lei, M., Dou, Y., Wang, S.
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==See Also==
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*[[WD-repeat protein 3D structures|WD-repeat protein 3D structures]]
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Description: Crystal structure of human WD repeat domain 5 with compound MM-101
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Bernard D]]
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[[Category: Cao F]]
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[[Category: Chen Y]]
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[[Category: Dou Y]]
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[[Category: Karatas H]]
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[[Category: Lei M]]
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[[Category: Liu L]]
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[[Category: Townsend EC]]
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[[Category: Wang S]]

Current revision

Crystal structure of human WD repeat domain 5 with compound MM-101

PDB ID 4gm3

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