This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
4gqs
From Proteopedia
(Difference between revisions)
| (3 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | [[Image:4gqs.png|left|200px]] | ||
| - | + | ==Structure of Human Microsomal Cytochrome P450 (CYP) 2C19== | |
| + | <StructureSection load='4gqs' size='340' side='right'caption='[[4gqs]], [[Resolution|resolution]] 2.87Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4gqs]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GQS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GQS FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.87Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0XV:(4-HYDROXY-3,5-DIMETHYLPHENYL)(2-METHYL-1-BENZOFURAN-3-YL)METHANONE'>0XV</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gqs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gqs OCA], [https://pdbe.org/4gqs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gqs RCSB], [https://www.ebi.ac.uk/pdbsum/4gqs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gqs ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/CP2CJ_HUMAN CP2CJ_HUMAN] Resistance to clopidogrel;Antidepressant or antipsychotics toxicity or dose selection;Voriconazole toxicity. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CP2CJ_HUMAN CP2CJ_HUMAN] Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine. | ||
| - | == | + | ==See Also== |
| - | + | *[[Cytochrome P450 3D structures|Cytochrome P450 3D structures]] | |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | + | ||
| - | [[ | + | |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Johnson EF]] |
| - | [[Category: | + | [[Category: Reynald RL]] |
| - | [[Category: | + | [[Category: Sansen S]] |
| - | [[Category: | + | [[Category: Stout CD]] |
| - | + | ||
| - | + | ||
| - | + | ||
Current revision
Structure of Human Microsomal Cytochrome P450 (CYP) 2C19
| |||||||||||
