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4grw

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'''Unreleased structure'''
 
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The entry 4grw is ON HOLD until Jan 23 2015
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==Structure of a complex of human IL-23 with 3 Nanobodies (Llama vHHs)==
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<StructureSection load='4grw' size='340' side='right'caption='[[4grw]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4grw]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GRW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GRW FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.55&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4grw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4grw OCA], [https://pdbe.org/4grw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4grw RCSB], [https://www.ebi.ac.uk/pdbsum/4grw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4grw ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/IL23A_HUMAN IL23A_HUMAN] Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.<ref>PMID:11114383</ref> <ref>PMID:12023369</ref> <ref>PMID:16424222</ref>
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Authors: Desmyter, A., Spinelli, S., Button, C., Saunders, M., de Haard, H., Rommelaere, H., Union, A., Cambillau, C.
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==See Also==
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*[[Antibody 3D structures|Antibody 3D structures]]
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Description: Structure of a complex of human IL-23 with 3 Nanobodies (Llama vHHs)
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*[[Interleukin 3D structures|Interleukin 3D structures]]
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*[[Transcription initiation factors 3D structures|Transcription initiation factors 3D structures]]
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*[[3D structures of non-human antibody|3D structures of non-human antibody]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Lama glama]]
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[[Category: Large Structures]]
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[[Category: Button C]]
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[[Category: Cambillau C]]
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[[Category: Desmyter A]]
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[[Category: Rommelaere H]]
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[[Category: Saunders M]]
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[[Category: Spinelli S]]
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[[Category: Union A]]
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[[Category: De Haard H]]

Current revision

Structure of a complex of human IL-23 with 3 Nanobodies (Llama vHHs)

PDB ID 4grw

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