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8c0k
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==fragment-linked stabilizer for ERa - 14-3-3 interaction (1075302)== | |
| - | + | <StructureSection load='8c0k' size='340' side='right'caption='[[8c0k]], [[Resolution|resolution]] 1.40Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8c0k]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8C0K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8C0K FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SOI:~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-4-(4-chloranylphenoxy)piperidine-4-carboxamide'>SOI</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr> |
| - | [[Category: Ottmann | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8c0k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8c0k OCA], [https://pdbe.org/8c0k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8c0k RCSB], [https://www.ebi.ac.uk/pdbsum/8c0k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8c0k ProSAT]</span></td></tr> |
| - | [[Category: Vandenboorn | + | </table> |
| - | [[Category: Visser | + | == Function == |
| + | [https://www.uniprot.org/uniprot/1433S_HUMAN 1433S_HUMAN] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity). p53-regulated inhibitor of G2/M progression. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Ottmann C]] | ||
| + | [[Category: Vandenboorn EMF]] | ||
| + | [[Category: Visser EJ]] | ||
Current revision
fragment-linked stabilizer for ERa - 14-3-3 interaction (1075302)
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