UV excision repair protein
From Proteopedia
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| - | <StructureSection load='' size='350' side='right' caption='Structure of yeast Rad23 (green) complex with Rad4 (grey) (PDB entry [[2qsf]])' scene=''> | + | <StructureSection load='2qsf' size='350' side='right' caption='Structure of yeast Rad23 (green) complex with Rad4 (grey) (PDB entry [[2qsf]])' scene=''> |
== Function == | == Function == | ||
| - | '''UV excision repair protein''' (Rad23) is a yeast protein involved in nucleotide excision repair. The human homologs are '''hHR23A''' and '''hHR23B'''. hHR23A plays a role in translocating polyubiquitinated proteins to the proteasome. | + | '''UV excision repair protein''' ('''Rad23''') is a yeast protein involved in nucleotide excision repair. The human homologs are '''hHR23A''' and '''hHR23B'''. hHR23A plays a role in translocating polyubiquitinated proteins to the proteasome. |
== Structural highlights == | == Structural highlights == | ||
| - | The protein contains a modular domain structure consisting of ubiquitin-like domain, ubiquitin-associated domain and XPC(xeroderma pigmentosum group C protein)-binding domain<ref>PMID:21047872</ref>. | + | The protein contains a modular domain structure consisting of ubiquitin-like domain, ubiquitin-associated domain and XPC (xeroderma pigmentosum group C protein)-binding domain<ref>PMID:21047872</ref>. |
| - | + | == 3D Structures of UV excision repair protein == | |
| - | == 3D Structures of | + | |
| - | + | [[UV excision repair protein 3D structures]] | |
| - | + | ||
| - | *Rad23 | ||
| - | |||
| - | **[[2nbu]] – yRad23 UBA domain – yeast - NMR<br /> | ||
| - | **[[2qsf]] – yRad23 + Rad4 <br /> | ||
| - | **[[2qsg]], [[2qsh]], [[4yir]] – yRad23 + Rad4 + DNA <br /> | ||
| - | **[[1x3w]], [[3esw]] – yRad23 XPC-binding domain + peptide:N-glycanase<br /> | ||
| - | **[[1x3z]] – yRad23 XPC-binding domain + peptide:N-glycanase + peptide<br /> | ||
| - | **[[2nbw]] – yRad23 UBA domain + RPN1 - NMR<br /> | ||
| - | **[[3m62]] – yRad23 UBA domain + Ufd2 <br /> | ||
| - | |||
| - | *Rad23 homolog hHR23 A | ||
| - | |||
| - | **[[1oqy]], [[1qze]] – hHR23A – human - NMR<br /> | ||
| - | **[[1f4i]] – hHR23A C-terminal domain (mutant) - NMR<br /> | ||
| - | **[[1ify]] – hHR23A internal UBA domain - NMR<br /> | ||
| - | **[[5xbo]] – hHR23A internal UBA domain + ubiquitin - NMR<br /> | ||
| - | **[[1p98]], [[2wyq]] – hHR23A UBA domain - NMR<br /> | ||
| - | **[[1p9d]] – hHR23A UBA domain + S5a - NMR<br /> | ||
| - | **[[1tp4]] – hHR23A XPC-binding domain - NMR<br /> | ||
| - | |||
| - | *Rad23 homolog hHR23 B | ||
| - | |||
| - | **[[1p1a]] – hHR23B UBA domain - NMR<br /> | ||
| - | **[[1pve]] – hHR23B XPC-binding domain - NMR<br /> | ||
| - | **[[1uel]] – hHR23B UBA domain + S5a - NMR<br /> | ||
| - | **[[1x3w]] – HR23B XPC-binding domain + peptide:N-glycanase - mouse<br /> | ||
| - | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
| + | </StructureSection> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
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