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Vinculin
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<StructureSection load='1st6' size='340' side='right' caption='Chicken full-length metavinculin, [[1st6]]' scene='' > | <StructureSection load='1st6' size='340' side='right' caption='Chicken full-length metavinculin, [[1st6]]' scene='' > | ||
| - | [[Vinculin|Vinculins]] (VCLs) are involved in adhesion by linking integrin molecules to the actin cytoskeleton. Its head domain (Vd1) can bind to [[Talin|talin]] or to [[Actinin|alpha-actinin]] at their respective VCL Binding Sites (VBS). | + | == Function == |
| - | + | [[Vinculin|Vinculins]] (VCLs) are involved in adhesion by linking integrin molecules to the actin cytoskeleton. Its head domain (Vd1) can bind to [[Talin|talin]] or to [[Actinin|alpha-actinin]] at their respective VCL Binding Sites (VBS)<ref>PMID:11152287</ref>. The protein raver1 RNA Recognition Motif (RRM) forms a complex with VCL or m-VCL. '''Metavinculin''' (m-VCL) is a splice version of VCL containing an extra ca. 70 amino acids in the C-terminal domain. | |
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| - | + | == Relevance == | |
| - | + | Loss of VCL could be used as a prognostic factor for colorectal cancer se it promotes metastasis<ref>PMID:25496021</ref>. | |
| - | + | == Disease == | |
| + | Mutation in m-VCL can yield cardiomyopathic phenotype<ref>PMID:16236538</ref>. | ||
| - | + | == Structural highlights == | |
| - | + | <scene name='Sandbox_27/Role_i997_vinculin_head-tail_1/1'>Vinculin Autoinhibition</scene> is achieved through a high affinity intramolecular interaction between tail (orange) and head (aqua) domains ([[1st6]]). Energetically, I997 is key to maintaining this autoinhibition. | |
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| - | + | == 3D Structures of Vinculin == | |
| + | [[Vinculin 3D structures]] | ||
| - | **[[3myi]] – m-VCL tail domain <br /> | ||
| - | **[[3rf3]] - hm-VCL + invasin IPAA<br /> | ||
| - | **[[3s90]] - hm-VCL head domain + mTalin-1 peptide<br /> | ||
| - | **[[4dj9]] - hm-VCL head domain + hTalin-1 peptide <br /> | ||
| - | **[[3tj5]] - hm-VCL head domain + Sca-family protein peptide<br /> | ||
| - | **[[3tj6]] - hm-VCL head domain + protein Ps 120 peptide<br /> | ||
| - | **[[4ehp]] - hm-VCL head domain + catenin α-1 residues 277-382<br /> | ||
| - | **[[3vf0]] – hm-VCL residues 856-1134 + ribonucleoprotein PTB-binding<br /> | ||
| - | **[[2gdc]] – cm-VCL Vd1+SfInvasin C-terminal <br /> | ||
| - | **[[1xwj]] - cm-VCL Vd1+cTalin VBS3<br /> | ||
| - | **[[1zvz]], [[1zw2]], [[1zw3]], [[1u6h]] - cm-VCL Vd1+cTalin rod<br /> | ||
| - | **[[1st6]] – cm-VCL<br /> | ||
| - | **[[4e17]], [[4e18]] - cm-VCL Vd1 + catenin α-1 VCL-binding domain | ||
| - | }} | ||
==References== | ==References== | ||
<references /> | <references /> | ||
| + | </StructureSection> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
*Created with the participation of [[User:Susan Craig|Susan Craig]]. | *Created with the participation of [[User:Susan Craig|Susan Craig]]. | ||
Current revision
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- Created with the participation of Susan Craig.
