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Vinculin
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== Structural highlights == | == Structural highlights == | ||
<scene name='Sandbox_27/Role_i997_vinculin_head-tail_1/1'>Vinculin Autoinhibition</scene> is achieved through a high affinity intramolecular interaction between tail (orange) and head (aqua) domains ([[1st6]]). Energetically, I997 is key to maintaining this autoinhibition. | <scene name='Sandbox_27/Role_i997_vinculin_head-tail_1/1'>Vinculin Autoinhibition</scene> is achieved through a high affinity intramolecular interaction between tail (orange) and head (aqua) domains ([[1st6]]). Energetically, I997 is key to maintaining this autoinhibition. | ||
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== 3D Structures of Vinculin == | == 3D Structures of Vinculin == | ||
| + | [[Vinculin 3D structures]] | ||
| - | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| - | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
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| - | *Vinculin; Domains - head 140-327; tail 878-1066 | ||
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| - | **[[1tr2]], [[6fuy]] – hVCL - human<br /> | ||
| - | **[[3h2u]] – hVCL head domain + raver1 RRM <br /> | ||
| - | **[[2ibf]], [[2hsq]], [[2gww]] - hVCL head domain + SfVCL binding sites from ''Shigella flexneri''<br /> | ||
| - | **[[1ydi]] - hVCL head domain +hActinin VBS<br /> | ||
| - | **[[1syq]], [[1rkc]], [[1rke]] – hVCL head domain +hTalin VBS<br /> | ||
| - | **[[1qkr]] – hVCL tail domain<br /> | ||
| - | **[[3h2v]] - hVCL tail domain + raver1 RRM<br /> | ||
| - | **[[4pr9]] - hVCL tail domain + lipid<br /> | ||
| - | **[[3jbi]] - hVCL tail domain + actin – Cryo-EM<br /> | ||
| - | **[[6nr7]] - cVCL – chicken<br /> | ||
| - | **[[1t01]] - cVCL head domain +mTalin VBS<br /> | ||
| - | **[[3zdl]] – cVCL head domain + amyloid β precursor protein N terminal<br /> | ||
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| - | *Metavinculin; Domains - head 1-256; tail 959-1134 | ||
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| - | **[[6fuy]] - hm-VCL <br /> | ||
| - | **[[3rf3]] - hm-VCL head domain + invasin IPAA<br /> | ||
| - | **[[3s90]] - hm-VCL head domain + mTalin-1 peptide<br /> | ||
| - | **[[4dj9]] - hm-VCL head domain + hTalin-1 peptide <br /> | ||
| - | **[[6fq4]] - hm-VCL head domain + TARP peptide <br /> | ||
| - | **[[3tj5]] - hm-VCL head domain + Sca-family protein peptide<br /> | ||
| - | **[[3tj6]] - hm-VCL head domain + protein Ps 120 peptide<br /> | ||
| - | **[[4ehp]], [[5y04]] - hm-VCL head domain + catenin α-1 residues 277-382<br /> | ||
| - | **[[3myi]] – hm-VCL tail domain <br /> | ||
| - | **[[5l0f]], [[5l0i]], [[5l0j]] - hm-VCL tail domain (mutant)<br /> | ||
| - | **[[5l0c]], [[5l0d]] - hm-VCL tail domain + lipid<br /> | ||
| - | **[[5l0g]], [[5l0h]] - hm-VCL tail domain (mutant) + lipid<br /> | ||
| - | **[[3jbk]] – hm-VCL tail domain + actin – Cryo-EM<br /> | ||
| - | **[[3vf0]] – hm-VCL tail domain + ribonucleoprotein PTB-binding<br /> | ||
| - | **[[1st6]] – cm-VCL<br /> | ||
| - | **[[2gdc]] – cm-VCL head domain +SfInvasin C-terminal <br /> | ||
| - | **[[1xwj]] - cm-VCL head domain +cTalin VBS3<br /> | ||
| - | **[[1zvz]], [[1zw2]], [[1zw3]], [[1u6h]] - cm-VCL head domain +cTalin rod<br /> | ||
| - | **[[6fq4]] – cm-VCL head domain + TARP-VBS1<br /> | ||
| - | **[[4e17]], [[4e18]] - cm-VCL head domain + catenin α-1 VCL-binding domain | ||
| - | }} | ||
==References== | ==References== | ||
<references /> | <references /> | ||
| + | </StructureSection> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
*Created with the participation of [[User:Susan Craig|Susan Craig]]. | *Created with the participation of [[User:Susan Craig|Susan Craig]]. | ||
Current revision
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- Created with the participation of Susan Craig.
