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8uke
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of Norbelladine O-methyltransferase variant in complex with SAH== | |
| - | + | <StructureSection load='8uke' size='340' side='right'caption='[[8uke]], [[Resolution|resolution]] 2.40Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8uke]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Narcissus_aff._pseudonarcissus_MK-2014 Narcissus aff. pseudonarcissus MK-2014]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8UKE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8UKE FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8uke FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8uke OCA], [https://pdbe.org/8uke PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8uke RCSB], [https://www.ebi.ac.uk/pdbsum/8uke PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8uke ProSAT]</span></td></tr> |
| - | [[Category: Kim | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/NOMT_NARAP NOMT_NARAP] 4'-O-methyltransferase converting norbelladine to 4'-O-methylnorbelladine. 4'-O-methylnorbelladine is a precursor to all Amaryllidaceae alkaloids such as galanthamine, lycorine and haemanthamine, and including haemanthamine- and crinamine-type alkaloids, promising anticancer agents. Can use norbelladine, N-methylnorbelladine and dopamine as substrate, but not caffeic acid, vanillin, 3,4-dihydroxybenzaldehyde and tyramine.<ref>PMID:25061748</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Narcissus aff. pseudonarcissus MK-2014]] | ||
| + | [[Category: Kim W]] | ||
| + | [[Category: Zhang YJ]] | ||
Current revision
Crystal Structure of Norbelladine O-methyltransferase variant in complex with SAH
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