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3kmp

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{{Seed}}
 
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[[Image:3kmp.jpg|left|200px]]
 
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<!--
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==Crystal Structure of SMAD1-MH1/DNA complex==
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The line below this paragraph, containing "STRUCTURE_3kmp", creates the "Structure Box" on the page.
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<StructureSection load='3kmp' size='340' side='right'caption='[[3kmp]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3kmp]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KMP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KMP FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_3kmp| PDB=3kmp | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3kmp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kmp OCA], [https://pdbe.org/3kmp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3kmp RCSB], [https://www.ebi.ac.uk/pdbsum/3kmp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3kmp ProSAT]</span></td></tr>
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</table>
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===Crystal Structure of SMAD1-MH1/DNA complex===
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== Function ==
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[https://www.uniprot.org/uniprot/SMAD1_MOUSE SMAD1_MOUSE] Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD) (By similarity). May play a role in the initiation and maintenance of spermatogenesis. SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1 (By similarity). May act synergistically with SMAD4 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression (PubMed:15329343).[UniProtKB:Q15797]<ref>PMID:15329343</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 20147459 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/km/3kmp_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_20147459}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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3KMP is a 4 chains structure with sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KMP OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3kmp ConSurf].
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<div style="clear:both"></div>
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==Reference==
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== References ==
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<ref group="xtra">PMID:20147459</ref><references group="xtra"/>
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Baburajendran, N.]]
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[[Category: Baburajendran N]]
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[[Category: Jauch, R.]]
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[[Category: Jauch R]]
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[[Category: Kolatkar, P R.]]
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[[Category: Kolatkar PR]]
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[[Category: Narasimhan, K.]]
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[[Category: Narasimhan K]]
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[[Category: Palasingam, P.]]
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[[Category: Palasingam P]]
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[[Category: Beta hairpin]]
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[[Category: Mh1 domain]]
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[[Category: Nucleus]]
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[[Category: Protein-dna complex]]
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[[Category: Sbe dna]]
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[[Category: Smad1]]
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[[Category: Transcription]]
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[[Category: Transcription regulation]]
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[[Category: Transcription regulator-dna complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 25 13:47:54 2010''
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Current revision

Crystal Structure of SMAD1-MH1/DNA complex

PDB ID 3kmp

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