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3ngo
From Proteopedia
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| - | {{STRUCTURE_3ngo| PDB=3ngo | SCENE= }} | ||
| - | ===Crystal structure of the human CNOT6L nuclease domain in complex with poly(A) DNA=== | ||
| - | {{ABSTRACT_PUBMED_20628353}} | ||
| - | == | + | ==Crystal structure of the human CNOT6L nuclease domain in complex with poly(A) DNA== |
| - | [[http://www.uniprot.org/uniprot/CNO6L_HUMAN CNO6L_HUMAN | + | <StructureSection load='3ngo' size='340' side='right'caption='[[3ngo]], [[Resolution|resolution]] 2.20Å' scene=''> |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3ngo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NGO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NGO FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ngo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ngo OCA], [https://pdbe.org/3ngo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ngo RCSB], [https://www.ebi.ac.uk/pdbsum/3ngo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ngo ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CNO6L_HUMAN CNO6L_HUMAN] Plays a role in the deadenylation of mRNAs in the cytoplasm. Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. May be involved in the deadenylation-dependent degradation of mRNAs through the 3'-UTR AU-rich element-mediated mechanism. Involved in deadenylation-dependent degradation of CDKN1B mRNA.<ref>PMID:17452450</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ng/3ngo_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ngo ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| - | == | + | ==See Also== |
| - | [[ | + | *[[Ribonuclease 3D structures|Ribonuclease 3D structures]] |
| - | + | == References == | |
| - | == | + | <references/> |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Bartlam | + | [[Category: Large Structures]] |
| - | [[Category: Morita | + | [[Category: Bartlam M]] |
| - | [[Category: Rao | + | [[Category: Morita M]] |
| - | [[Category: Wang | + | [[Category: Rao Z]] |
| - | [[Category: Yamamoto | + | [[Category: Wang H]] |
| - | [[Category: Yang | + | [[Category: Yamamoto T]] |
| - | + | [[Category: Yang W]] | |
| - | + | ||
Current revision
Crystal structure of the human CNOT6L nuclease domain in complex with poly(A) DNA
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Categories: Homo sapiens | Large Structures | Bartlam M | Morita M | Rao Z | Wang H | Yamamoto T | Yang W
