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3rnv
From Proteopedia
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| - | [[Image:3rnv.jpg|left|200px]] | ||
| - | + | ==Structure of the autocatalytic cysteine protease domain of potyvirus helper-component proteinase== | |
| - | + | <StructureSection load='3rnv' size='340' side='right'caption='[[3rnv]], [[Resolution|resolution]] 2.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3rnv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Turnip_mosaic_virus Turnip mosaic virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RNV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RNV FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rnv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rnv OCA], [https://pdbe.org/3rnv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rnv RCSB], [https://www.ebi.ac.uk/pdbsum/3rnv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rnv ProSAT]</span></td></tr> | |
| - | + | </table> | |
| - | + | == Function == | |
| - | + | [https://www.uniprot.org/uniprot/POLG_TUMVJ POLG_TUMVJ] Capsid protein: involved in aphid transmission, cell-to-cell and systemis movement, encapsidation of the viral RNA and in the regulation of viral RNA amplification. Nuclear inclusion protein B: a RNA-dependent RNA polymerase that plays an essential role in the virus replication. Helper component proteinase: required for aphid transmission and also has proteolytic activity. Only cleaves a Gly-Gly dipeptide at its own C-terminus. Interacts with virions and aphid stylets. Acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs. May have RNA-binding activity (By similarity). Cytoplasmic inclusion protein: has helicase activity. It may be involved in replication (By similarity). Both 6K peptides are indispensable for virus replication (By similarity). Nuclear inclusion protein A: has RNA-binding and proteolytic activities. | |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | == | + | [[Category: Large Structures]] |
| - | [[3rnv]] is a 1 chain structure with sequence from [ | + | |
| - | [[ | + | |
[[Category: Turnip mosaic virus]] | [[Category: Turnip mosaic virus]] | ||
| - | [[Category: Ye | + | [[Category: Ye K]] |
Current revision
Structure of the autocatalytic cysteine protease domain of potyvirus helper-component proteinase
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