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3shy

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[[Image:3shy.png|left|200px]]
 
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{{STRUCTURE_3shy| PDB=3shy | SCENE= }}
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==Crystal structure of the PDE5A1 catalytic domain in complex with novel inhibitors==
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<StructureSection load='3shy' size='340' side='right'caption='[[3shy]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
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===Crystal structure of the PDE5A1 catalytic domain in complex with novel inhibitors===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3shy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SHY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SHY FirstGlance]. <br>
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{{ABSTRACT_PUBMED_21714539}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.647&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5FO:6-ETHYL-5-FLUORO-2-{5-[(4-METHYLPIPERAZIN-1-YL)SULFONYL]-2-PROPOXYPHENYL}PYRIMIDIN-4(3H)-ONE'>5FO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3shy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3shy OCA], [https://pdbe.org/3shy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3shy RCSB], [https://www.ebi.ac.uk/pdbsum/3shy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3shy ProSAT]</span></td></tr>
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[[3shy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SHY OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PDE5A_HUMAN PDE5A_HUMAN] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP.
==See Also==
==See Also==
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*[[Phosphodiesterase|Phosphodiesterase]]
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*[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:021714539</ref><references group="xtra"/>
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[[Category: 3',5'-cyclic-GMP phosphodiesterase]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Chen, T.]]
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[[Category: Large Structures]]
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[[Category: Chen, T T.]]
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[[Category: Chen T]]
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[[Category: Xu, Y C.]]
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[[Category: Chen TT]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Xu YC]]
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[[Category: Pde5a inhibitor]]
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Current revision

Crystal structure of the PDE5A1 catalytic domain in complex with novel inhibitors

PDB ID 3shy

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