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3v68

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==Crystal structure of Pyrococcus furiosus PF2050, a member of DUF2666 family protein==
==Crystal structure of Pyrococcus furiosus PF2050, a member of DUF2666 family protein==
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<StructureSection load='3v68' size='340' side='right' caption='[[3v68]], [[Resolution|resolution]] 1.56&Aring;' scene=''>
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<StructureSection load='3v68' size='340' side='right'caption='[[3v68]], [[Resolution|resolution]] 1.56&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3v68]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pyrfu Pyrfu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V68 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3V68 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3v68]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_furiosus_DSM_3638 Pyrococcus furiosus DSM 3638]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V68 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3V68 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.56&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PF2050 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=186497 PYRFU])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3v68 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v68 OCA], [http://pdbe.org/3v68 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3v68 RCSB], [http://www.ebi.ac.uk/pdbsum/3v68 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3v68 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3v68 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v68 OCA], [https://pdbe.org/3v68 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3v68 RCSB], [https://www.ebi.ac.uk/pdbsum/3v68 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3v68 ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/Q8TZE5_PYRFU Q8TZE5_PYRFU]
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Pyrococcus furiosus PF2050 is an uncharacterized putative protein that contains two DUF2666 domains. Functional and structural studies of PF2050 have not previously been performed. In this study, we determined the crystal structure of PF2050. The structure of PF2050 showed that the two DUF2666 domains interact tightly, forming a globular structure. Each DUF2666 domain comprises an antiparallel beta-sheet and an alpha-helical bundle. One side of the PF2050 structure has a positively charged basic cleft, which may have a DNA-binding function. Furthermore, we confirmed that PF2050 interacts with circular and linear dsDNA.
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Crystal structure of Pyrococcus furiosus PF2050, a member of the DUF2666 protein family.,Han BG, Jeong KC, Cho JW, Jeong BC, Song HK, Lee JY, Shin DH, Lee S, Lee BI FEBS Lett. 2012 May 7;586(9):1384-8. doi: 10.1016/j.febslet.2012.04.004. Epub, 2012 Apr 13. PMID:22616997<ref>PMID:22616997</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3v68" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Pyrfu]]
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[[Category: Large Structures]]
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[[Category: Han, B G]]
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[[Category: Pyrococcus furiosus DSM 3638]]
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[[Category: Lee, B I]]
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[[Category: Han BG]]
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[[Category: Dna binding protein]]
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[[Category: Lee BI]]
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[[Category: Double stranded dna]]
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[[Category: Duf2666]]
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Current revision

Crystal structure of Pyrococcus furiosus PF2050, a member of DUF2666 family protein

PDB ID 3v68

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