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3vi5

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[[Image:3vi5.png|left|200px]]
 
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{{STRUCTURE_3vi5| PDB=3vi5 | SCENE= }}
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==Human hematopoietic prostaglandin D synthase inhibitor complex structures==
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<StructureSection load='3vi5' size='340' side='right'caption='[[3vi5]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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===Human hematopoietic prostaglandin D synthase inhibitor complex structures===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3vi5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VI5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VI5 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_22418579}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=M4M:1-AMINO-9,10-DIOXO-4-[(4-SULFAMOYLPHENYL)AMINO]-9,10-DIHYDROANTHRACENE-2-SULFONIC+ACID'>M4M</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vi5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vi5 OCA], [https://pdbe.org/3vi5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vi5 RCSB], [https://www.ebi.ac.uk/pdbsum/3vi5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vi5 ProSAT]</span></td></tr>
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[[3vi5]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VI5 OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HPGDS_HUMAN HPGDS_HUMAN] Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide.<ref>PMID:10824118</ref> <ref>PMID:11672424</ref> <ref>PMID:9425264</ref> <ref>PMID:9353279</ref> <ref>PMID:12627223</ref> <ref>PMID:15113825</ref> <ref>PMID:16547010</ref> <ref>PMID:19939518</ref>
==See Also==
==See Also==
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*[[Prostaglandin D synthase|Prostaglandin D synthase]]
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*[[Glutathione S-transferase 3D structures|Glutathione S-transferase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:022418579</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Inoue, T.]]
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[[Category: Large Structures]]
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[[Category: Kado, Y.]]
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[[Category: Inoue T]]
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[[Category: Ca binding]]
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[[Category: Kado Y]]
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[[Category: Glutathione s transferase]]
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[[Category: Gsh binding]]
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[[Category: Isomerase]]
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[[Category: Isomerase-isomerase inhibitor complex]]
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[[Category: Prostaglandin h2 binding]]
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Human hematopoietic prostaglandin D synthase inhibitor complex structures

PDB ID 3vi5

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