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3vne

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[[Image:3vne.jpg|left|200px]]
 
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==Structure of the ebolavirus protein VP24 from Sudan==
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The line below this paragraph, containing "STRUCTURE_3vne", creates the "Structure Box" on the page.
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<StructureSection load='3vne' size='340' side='right'caption='[[3vne]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3vne]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sudan_ebolavirus Sudan ebolavirus]. The October 2014 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Ebola Virus Proteins'' by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2014_10 10.2210/rcsb_pdb/mom_2014_10]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VNE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VNE FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vne FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vne OCA], [https://pdbe.org/3vne PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vne RCSB], [https://www.ebi.ac.uk/pdbsum/3vne PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vne ProSAT]</span></td></tr>
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{{STRUCTURE_3vne| PDB=3vne | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/VP24_EBOSU VP24_EBOSU] Prevents the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) and IFN-gamma signaling pathways. Blocks the IFN-induced nuclear accumulation of host phosphorylated STAT1, by interacting with the STAT1-binding region of host importin alpha-1/KPNA1 protein, thereby inhibiting the latter. Without the activity of this protein, activated STAT1 would not enter the nucleus and be unable to activate IFN-induced genes. Plays a role in assembly of viral nucleocapsid and virion budding. May act as a minor matrix protein that plays a role in assembly of viral nucleocapsid and virion budding.
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===Structure of the ebolavirus protein VP24 from Sudan===
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==See Also==
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*[[VP24|VP24]]
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__TOC__
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</StructureSection>
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[[Category: Ebola Virus Proteins]]
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(as it appears on PubMed at http://www.pubmed.gov), where 22383882 is the PubMed ID number.
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[[Category: Large Structures]]
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[[Category: RCSB PDB Molecule of the Month]]
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{{ABSTRACT_PUBMED_22383882}}
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==About this Structure==
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[[3vne]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sudan_ebolavirus Sudan ebolavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VNE OCA].
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==Reference==
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<ref group="xtra">PMID:022383882</ref><references group="xtra"/>
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[[Category: Sudan ebolavirus]]
[[Category: Sudan ebolavirus]]
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[[Category: Zhang, A P.P.]]
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[[Category: Zhang APP]]
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[[Category: Ebolavirus]]
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[[Category: Ifn response pathway]]
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[[Category: Interferon antagonist]]
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[[Category: Karyopherin alpha]]
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[[Category: Reston]]
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[[Category: Stat1]]
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[[Category: Sudan]]
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[[Category: Viral protein]]
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[[Category: Vp24]]
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[[Category: Vp35]]
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[[Category: Zaire]]
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Current revision

Structure of the ebolavirus protein VP24 from Sudan

PDB ID 3vne

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OCA

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