This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


3vre

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:41, 20 March 2024) (edit) (undo)
 
Line 3: Line 3:
<StructureSection load='3vre' size='340' side='right'caption='[[3vre]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
<StructureSection load='3vre' size='340' side='right'caption='[[3vre]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[3vre]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mampr Mampr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VRE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VRE FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[3vre]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mammuthus_primigenius Mammuthus primigenius]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VRE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VRE FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3vfr|3vfr]], [[3vfg|3vfg]]</div></td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HBA-T2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=37349 MAMPR]), HBB/D ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=37349 MAMPR])</td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vre FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vre OCA], [https://pdbe.org/3vre PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vre RCSB], [https://www.ebi.ac.uk/pdbsum/3vre PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vre ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vre FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vre OCA], [https://pdbe.org/3vre PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vre RCSB], [https://www.ebi.ac.uk/pdbsum/3vre PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vre ProSAT]</span></td></tr>
</table>
</table>
-
<div style="background-color:#fffaf0;">
+
== Function ==
-
== Publication Abstract from PubMed ==
+
[https://www.uniprot.org/uniprot/D3U1H8_MAMPR D3U1H8_MAMPR]
-
The haemoglobin (Hb) of the extinct woolly mammoth has been recreated using recombinant genes expressed in Escherichia coli. The globin gene sequences were previously determined using DNA recovered from frozen cadavers. Although highly similar to the Hb of existing elephants, the woolly mammoth protein shows rather different responses to chloride ions and temperature. In particular, the heat of oxygenation is found to be much lower in mammoth Hb, which appears to be an adaptation to the harsh high-latitude climates of the Pleistocene Ice Ages and has been linked to heightened sensitivity of the mammoth protein to protons, chloride ions and organic phosphates relative to that of Asian elephants. To elucidate the structural basis for the altered homotropic and heterotropic effects, the crystal structures of mammoth Hb have been determined in the deoxy, carbonmonoxy and aquo-met forms. These models, which are the first structures of Hb from an extinct species, show many features reminiscent of human Hb, but underline how the delicate control of oxygen affinity relies on much more than simple overall quaternary-structure changes.
+
-
 
+
-
Structures of haemoglobin from woolly mammoth in liganded and unliganded states.,Noguchi H, Campbell KL, Ho C, Unzai S, Park SY, Tame JR Acta Crystallogr D Biol Crystallogr. 2012 Nov;68(Pt 11):1441-9. doi:, 10.1107/S0907444912029459. Epub 2012 Oct 18. PMID:23090393<ref>PMID:23090393</ref>
+
-
 
+
-
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+
-
</div>
+
-
<div class="pdbe-citations 3vre" style="background-color:#fffaf0;"></div>
+
==See Also==
==See Also==
*[[Hemoglobin 3D structures|Hemoglobin 3D structures]]
*[[Hemoglobin 3D structures|Hemoglobin 3D structures]]
-
== References ==
 
-
<references/>
 
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: Mampr]]
+
[[Category: Mammuthus primigenius]]
-
[[Category: Campbell, K L]]
+
[[Category: Campbell KL]]
-
[[Category: Ho, C]]
+
[[Category: Ho C]]
-
[[Category: Noguchi, H]]
+
[[Category: Noguchi H]]
-
[[Category: Park, S Y]]
+
[[Category: Park S-Y]]
-
[[Category: Tame, J R.H]]
+
[[Category: Tame JRH]]
-
[[Category: Oxygen storage/transport]]
+
-
[[Category: Oxygen transport]]
+
-
[[Category: Woolly mammoth hemoglobin]]
+

Current revision

The crystal structure of hemoglobin from woolly mammoth in the deoxy form

PDB ID 3vre

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3vre"
Personal tools