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3wlu

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==Crystal Structure of human galectin-9 NCRD with Selenolactose==
==Crystal Structure of human galectin-9 NCRD with Selenolactose==
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<StructureSection load='3wlu' size='340' side='right' caption='[[3wlu]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
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<StructureSection load='3wlu' size='340' side='right'caption='[[3wlu]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3wlu]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WLU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3WLU FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3wlu]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WLU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WLU FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LSE:2-(TRIMETHYLSILYL)ETHYL+4-O-BETA-D-GALACTOPYRANOSYL-6-SE-METHYL-6-SELENO-BETA-D-GLUCOPYRANOSIDE'>LSE</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2eak|2eak]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LSE:2-(TRIMETHYLSILYL)ETHYL+4-O-BETA-D-GALACTOPYRANOSYL-6-SE-METHYL-6-SELENO-BETA-D-GLUCOPYRANOSIDE'>LSE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wlu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wlu OCA], [http://pdbe.org/3wlu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3wlu RCSB], [http://www.ebi.ac.uk/pdbsum/3wlu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3wlu ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wlu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wlu OCA], [https://pdbe.org/3wlu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wlu RCSB], [https://www.ebi.ac.uk/pdbsum/3wlu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wlu ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/LEG9_HUMAN LEG9_HUMAN]] Binds galactosides. Has high affinity for the Forssman pentasaccharide. May play a role in thymocyte-epithelial interactions relevant to the biology of the thymus. Inhibits cell proliferation. It is a ligand for HAVCR2/TIM3. Induces T-helper type 1 lymphocyte (Th1) death. Isoform Short acts as an eosinophil chemoattractant.<ref>PMID:16286920</ref> <ref>PMID:18005988</ref> <ref>PMID:18977853</ref>
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[https://www.uniprot.org/uniprot/LEG9_HUMAN LEG9_HUMAN] Binds galactosides. Has high affinity for the Forssman pentasaccharide. May play a role in thymocyte-epithelial interactions relevant to the biology of the thymus. Inhibits cell proliferation. It is a ligand for HAVCR2/TIM3. Induces T-helper type 1 lymphocyte (Th1) death. Isoform Short acts as an eosinophil chemoattractant.<ref>PMID:16286920</ref> <ref>PMID:18005988</ref> <ref>PMID:18977853</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Seleno-lactoses have been successfully synthesized as candidates for mimicking carbohydrate ligands for human galectin-9 N-terminal carbohydrate recognition domain (NCRD). Selenium was introduced into the mono- or di-saccharides using p-methylselenobenzoic anhydride (Tol2Se) as a novel selenating reagent. The TolSe-substituted monosaccharides were converted into selenoglycosyl donors or acceptors, which were reacted with coupling partners to afford seleno-lactoses. The seleno-lactoses were converted to the target compounds. The structure of human galectin-9 NCRD co-crystallized with 6-MeSe-lactose was determined with single/multi-wavelength anomalous dispersion (SAD/MAD) phasing and was similar to that of the co-crystal with natural lactose.
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Expanded potential of seleno-carbohydrates as a molecular tool for X-ray structural determination of a carbohydrate-protein complex with single/multi-wavelength anomalous dispersion phasing.,Suzuki T, Makyio H, Ando H, Komura N, Menjo M, Yamada Y, Imamura A, Ishida H, Wakatsuki S, Kato R, Kiso M Bioorg Med Chem. 2014 Apr 1;22(7):2090-101. doi: 10.1016/j.bmc.2014.02.023. Epub , 2014 Feb 25. PMID:24631362<ref>PMID:24631362</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3wlu" style="background-color:#fffaf0;"></div>
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==See Also==
==See Also==
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*[[Galectin|Galectin]]
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*[[Galectin 3D structures|Galectin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Ando, H]]
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[[Category: Homo sapiens]]
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[[Category: Ishida, H]]
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[[Category: Large Structures]]
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[[Category: Kato, R]]
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[[Category: Ando H]]
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[[Category: Kiso, M]]
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[[Category: Ishida H]]
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[[Category: Makyio, H]]
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[[Category: Kato R]]
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[[Category: Suzuki, T]]
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[[Category: Kiso M]]
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[[Category: Wakatsuki, S]]
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[[Category: Makyio H]]
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[[Category: Yamada, Y]]
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[[Category: Suzuki T]]
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[[Category: Beta sandwich]]
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[[Category: Wakatsuki S]]
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[[Category: Carbohydrate binding]]
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[[Category: Yamada Y]]
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[[Category: Galectin]]
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[[Category: Selenolactose]]
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[[Category: Sugar binding protein]]
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Current revision

Crystal Structure of human galectin-9 NCRD with Selenolactose

PDB ID 3wlu

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