|
|
| (4 intermediate revisions not shown.) |
| Line 1: |
Line 1: |
| - | {{STRUCTURE_4dt1| PDB=4dt1 | SCENE= }} | |
| - | ===Crystal structure of the Psy3-Csm2 complex=== | |
| - | {{ABSTRACT_PUBMED_22465956}} | |
| | | | |
| - | ==Function== | + | ==Crystal structure of the Psy3-Csm2 complex== |
| - | [[http://www.uniprot.org/uniprot/CSM2_YEAST CSM2_YEAST]] Involved in chromosome segregation during meiosis. Promotes efficient recombinational repair and functions in the protection of the genome from spontaneous and induced DNA damage like mutations and gross chromosomal rearrangements (GCRs).<ref>PMID:11470404</ref> <ref>PMID:12972632</ref> <ref>PMID:15184655</ref> <ref>PMID:15654096</ref> <ref>PMID:19496932</ref> [[http://www.uniprot.org/uniprot/PSY3_YEAST PSY3_YEAST]] Required for resistance to the DNA-damaging agents methyl methanesulfonate (MMS), cisplatin and oxaliplatin, but not to mitomycin C. Plays a role in protection against mutation accumulation. May be a component of the recombination-repair pathway.<ref>PMID:12149442</ref> <ref>PMID:12482937</ref> <ref>PMID:12972632</ref> <ref>PMID:15173006</ref> <ref>PMID:15654096</ref> <ref>PMID:19496932</ref> | + | <StructureSection load='4dt1' size='340' side='right'caption='[[4dt1]], [[Resolution|resolution]] 1.90Å' scene=''> |
| - | | + | == Structural highlights == |
| - | ==About this Structure== | + | <table><tr><td colspan='2'>[[4dt1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DT1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DT1 FirstGlance]. <br> |
| - | [[4dt1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_s288c Saccharomyces cerevisiae s288c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DT1 OCA]. | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.899Å</td></tr> |
| - | | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EOH:ETHANOL'>EOH</scene></td></tr> |
| - | ==Reference== | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dt1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dt1 OCA], [https://pdbe.org/4dt1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dt1 RCSB], [https://www.ebi.ac.uk/pdbsum/4dt1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dt1 ProSAT]</span></td></tr> |
| - | <ref group="xtra">PMID:022465956</ref><references group="xtra"/><references/> | + | </table> |
| - | [[Category: Saccharomyces cerevisiae s288c]]
| + | == Function == |
| - | [[Category: Niu, L.]]
| + | [https://www.uniprot.org/uniprot/CSM2_YEAST CSM2_YEAST] Involved in chromosome segregation during meiosis. Promotes efficient recombinational repair and functions in the protection of the genome from spontaneous and induced DNA damage like mutations and gross chromosomal rearrangements (GCRs).<ref>PMID:11470404</ref> <ref>PMID:12972632</ref> <ref>PMID:15184655</ref> <ref>PMID:15654096</ref> <ref>PMID:19496932</ref> |
| - | [[Category: Tao, Y.]] | + | == References == |
| - | [[Category: Teng, M.]] | + | <references/> |
| - | [[Category: Dna binding protein]] | + | __TOC__ |
| - | [[Category: Dna damage repair]] | + | </StructureSection> |
| - | [[Category: Protein complex]] | + | [[Category: Large Structures]] |
| - | [[Category: Reca-like fold]]
| + | [[Category: Saccharomyces cerevisiae S288C]] |
| | + | [[Category: Niu L]] |
| | + | [[Category: Tao Y]] |
| | + | [[Category: Teng M]] |
| Structural highlights
Function
CSM2_YEAST Involved in chromosome segregation during meiosis. Promotes efficient recombinational repair and functions in the protection of the genome from spontaneous and induced DNA damage like mutations and gross chromosomal rearrangements (GCRs).[1] [2] [3] [4] [5]
References
- ↑ Rabitsch KP, Toth A, Galova M, Schleiffer A, Schaffner G, Aigner E, Rupp C, Penkner AM, Moreno-Borchart AC, Primig M, Esposito RE, Klein F, Knop M, Nasmyth K. A screen for genes required for meiosis and spore formation based on whole-genome expression. Curr Biol. 2001 Jul 10;11(13):1001-9. PMID:11470404
- ↑ Huang ME, Rio AG, Nicolas A, Kolodner RD. A genomewide screen in Saccharomyces cerevisiae for genes that suppress the accumulation of mutations. Proc Natl Acad Sci U S A. 2003 Sep 30;100(20):11529-34. Epub 2003 Sep 12. PMID:12972632 doi:http://dx.doi.org/10.1073/pnas.2035018100
- ↑ Smith S, Hwang JY, Banerjee S, Majeed A, Gupta A, Myung K. Mutator genes for suppression of gross chromosomal rearrangements identified by a genome-wide screening in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A. 2004 Jun 15;101(24):9039-44. Epub 2004 Jun 7. PMID:15184655 doi:10.1073/pnas.0403093101
- ↑ Shor E, Weinstein J, Rothstein R. A genetic screen for top3 suppressors in Saccharomyces cerevisiae identifies SHU1, SHU2, PSY3 and CSM2: four genes involved in error-free DNA repair. Genetics. 2005 Mar;169(3):1275-89. Epub 2005 Jan 16. PMID:15654096 doi:10.1534/genetics.104.036764
- ↑ Ball LG, Zhang K, Cobb JA, Boone C, Xiao W. The yeast Shu complex couples error-free post-replication repair to homologous recombination. Mol Microbiol. 2009 Jul;73(1):89-102. Epub 2009 Jun 1. PMID:19496932 doi:MMI6748
|
