This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


4ef4

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:49, 20 March 2024) (edit) (undo)
 
(4 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:4ef4.png|left|200px]]
 
-
<!--
+
==Crystal structure of STING CTD complex with c-di-GMP==
-
The line below this paragraph, containing "STRUCTURE_4ef4", creates the "Structure Box" on the page.
+
<StructureSection load='4ef4' size='340' side='right'caption='[[4ef4]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[4ef4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EF4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EF4 FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.147&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C2E:9,9-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d 3,2-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one)'>C2E</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-
{{STRUCTURE_4ef4| PDB=4ef4 | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ef4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ef4 OCA], [https://pdbe.org/4ef4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ef4 RCSB], [https://www.ebi.ac.uk/pdbsum/4ef4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ef4 ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/STING_HUMAN STING_HUMAN] Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm. Acts by recognizing and binding cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced in response to DNA virus in the cytosol: upon binding of c-di-GMP or cGAMP, autoinhibition is alleviated and TMEM173/STING is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti-viral state. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway.<ref>PMID:18818105</ref> <ref>PMID:18724357</ref> <ref>PMID:19776740</ref> <ref>PMID:19433799</ref> <ref>PMID:21074459</ref> <ref>PMID:21947006</ref> <ref>PMID:23258412</ref>
-
===Crystal structure of STING CTD complex with c-di-GMP===
+
==See Also==
-
 
+
*[[Stimulator of interferon genes protein|Stimulator of interferon genes protein]]
-
 
+
*[[Stimulator of interferon genes protein 3D structures|Stimulator of interferon genes protein 3D structures]]
-
<!--
+
== References ==
-
The line below this paragraph, {{ABSTRACT_PUBMED_22579474}}, adds the Publication Abstract to the page
+
<references/>
-
(as it appears on PubMed at http://www.pubmed.gov), where 22579474 is the PubMed ID number.
+
__TOC__
-
-->
+
</StructureSection>
-
{{ABSTRACT_PUBMED_22579474}}
+
-
 
+
-
==About this Structure==
+
-
[[4ef4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EF4 OCA].
+
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:022579474</ref><references group="xtra"/>
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Jiang, Y.]]
+
[[Category: Large Structures]]
-
[[Category: Li, Y.]]
+
[[Category: Jiang Y]]
-
[[Category: Liu, Z J.]]
+
[[Category: Li Y]]
-
[[Category: Niu, F.]]
+
[[Category: Liu Z-J]]
-
[[Category: Ouyang, S.]]
+
[[Category: Niu F]]
-
[[Category: Qiu, W.]]
+
[[Category: Ouyang S]]
-
[[Category: Ru, H.]]
+
[[Category: Qiu W]]
-
[[Category: Shaw, N.]]
+
[[Category: Ru H]]
-
[[Category: Zhu, Y.]]
+
[[Category: Shaw N]]
-
[[Category: 5 helices and 5 strands in single domain]]
+
[[Category: Zhu Y]]
-
[[Category: C-di-gmp]]
+
-
[[Category: Dimerization]]
+
-
[[Category: Immune system]]
+
-
[[Category: Innate immune system]]
+
-
[[Category: Sting/mita/eris/mpys/tmem173]]
+
-
[[Category: Type i interferon]]
+

Current revision

Crystal structure of STING CTD complex with c-di-GMP

PDB ID 4ef4

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4ef4"
Personal tools