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4g4y
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of OmpA peptidoglycan-binding domain from Acinetobacter baumannii== | |
| - | + | <StructureSection load='4g4y' size='340' side='right'caption='[[4g4y]], [[Resolution|resolution]] 1.70Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4g4y]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Acinetobacter_baumannii Acinetobacter baumannii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G4Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4G4Y FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7Å</td></tr> | |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ALA:ALANINE'>ALA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4g4y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g4y OCA], [https://pdbe.org/4g4y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4g4y RCSB], [https://www.ebi.ac.uk/pdbsum/4g4y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4g4y ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/OMP38_ACIB2 OMP38_ACIB2] Functions as a porin (PubMed:9928952). Induces apoptosis in human cell lines through caspase-dependent and AIF-dependent pathways. Purified Omp38 enters host cell and localizes to the mitochondria, which presumably leads to a release of proapoptotic molecules such as cytochrome c and AIF (apoptosis-inducing factor) (PubMed:16008580). Binds peptidoglycan, contributes to cell wall maintenance (Probable).<ref>PMID:16008580</ref> <ref>PMID:9928952</ref> <ref>PMID:16008580</ref> <ref>PMID:21965596</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Acinetobacter baumannii]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Kim HY]] | ||
| + | [[Category: Lee WC]] | ||
| + | [[Category: Park JS]] | ||
| + | [[Category: Song JH]] | ||
Current revision
Crystal structure of OmpA peptidoglycan-binding domain from Acinetobacter baumannii
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