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4l5o

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==Crystal structure of 26 kDa GST D26H mutant of Clonorchis sinensis==
==Crystal structure of 26 kDa GST D26H mutant of Clonorchis sinensis==
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<StructureSection load='4l5o' size='340' side='right' caption='[[4l5o]], [[Resolution|resolution]] 2.09&Aring;' scene=''>
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<StructureSection load='4l5o' size='340' side='right'caption='[[4l5o]], [[Resolution|resolution]] 2.09&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4l5o]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Closi Closi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L5O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4L5O FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4l5o]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Clonorchis_sinensis Clonorchis sinensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L5O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4L5O FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.09&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3iso|3iso]], [[4l5l|4l5l]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4l5o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l5o OCA], [http://pdbe.org/4l5o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4l5o RCSB], [http://www.ebi.ac.uk/pdbsum/4l5o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4l5o ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4l5o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l5o OCA], [https://pdbe.org/4l5o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4l5o RCSB], [https://www.ebi.ac.uk/pdbsum/4l5o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4l5o ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/Q25595_CLOSI Q25595_CLOSI]
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The crystal structures of CsGST in two different space groups revealed that Asp26 and His79 coordinate a zinc ion. In one space group, His46 of an adjacent molecule participates in the coordination within 2.0A. In the other space group, Asp26, His79 and a water molecule coordinate a zinc ion. The CsGST-D26H structure showed that four histidine residues - His26 and His79 from one molecule and the same residues from a symmetry-related neighboring molecule - coordinate a zinc ion. The coordinated zinc ions are located between two molecules and mediate molecular contacts within the crystal.
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Crystal structures of 26kDa Clonorchis sinensis glutathione S-transferase reveal zinc binding and putative metal binding.,Han YH, Hong SJ, Cheong HK, Chung YJ Biochem Biophys Res Commun. 2013 Aug 23;438(2):457-61. doi:, 10.1016/j.bbrc.2013.07.102. Epub 2013 Jul 31. PMID:23916611<ref>PMID:23916611</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 4l5o" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Closi]]
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[[Category: Clonorchis sinensis]]
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[[Category: Chung, Y J]]
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[[Category: Large Structures]]
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[[Category: Han, Y H]]
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[[Category: Chung YJ]]
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[[Category: Gsh binding]]
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[[Category: Han YH]]
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[[Category: Transferase]]
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Current revision

Crystal structure of 26 kDa GST D26H mutant of Clonorchis sinensis

PDB ID 4l5o

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