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4l5o
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4l5o]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Clonorchis_sinensis Clonorchis sinensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L5O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4L5O FirstGlance]. <br> | <table><tr><td colspan='2'>[[4l5o]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Clonorchis_sinensis Clonorchis sinensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L5O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4L5O FirstGlance]. <br> | ||
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.09Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4l5o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l5o OCA], [https://pdbe.org/4l5o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4l5o RCSB], [https://www.ebi.ac.uk/pdbsum/4l5o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4l5o ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4l5o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l5o OCA], [https://pdbe.org/4l5o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4l5o RCSB], [https://www.ebi.ac.uk/pdbsum/4l5o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4l5o ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/Q25595_CLOSI Q25595_CLOSI] | [https://www.uniprot.org/uniprot/Q25595_CLOSI Q25595_CLOSI] | ||
| - | <div style="background-color:#fffaf0;"> | ||
| - | == Publication Abstract from PubMed == | ||
| - | The crystal structures of CsGST in two different space groups revealed that Asp26 and His79 coordinate a zinc ion. In one space group, His46 of an adjacent molecule participates in the coordination within 2.0A. In the other space group, Asp26, His79 and a water molecule coordinate a zinc ion. The CsGST-D26H structure showed that four histidine residues - His26 and His79 from one molecule and the same residues from a symmetry-related neighboring molecule - coordinate a zinc ion. The coordinated zinc ions are located between two molecules and mediate molecular contacts within the crystal. | ||
| - | |||
| - | Crystal structures of 26kDa Clonorchis sinensis glutathione S-transferase reveal zinc binding and putative metal binding.,Han YH, Hong SJ, Cheong HK, Chung YJ Biochem Biophys Res Commun. 2013 Aug 23;438(2):457-61. doi:, 10.1016/j.bbrc.2013.07.102. Epub 2013 Jul 31. PMID:23916611<ref>PMID:23916611</ref> | ||
| - | |||
| - | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| - | </div> | ||
| - | <div class="pdbe-citations 4l5o" style="background-color:#fffaf0;"></div> | ||
| - | == References == | ||
| - | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Current revision
Crystal structure of 26 kDa GST D26H mutant of Clonorchis sinensis
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