This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


4quz

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:59, 20 March 2024) (edit) (undo)
 
(2 intermediate revisions not shown.)
Line 1: Line 1:
==Crystal structure of Feline Norovirus P Domain==
==Crystal structure of Feline Norovirus P Domain==
-
<StructureSection load='4quz' size='340' side='right' caption='[[4quz]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
+
<StructureSection load='4quz' size='340' side='right'caption='[[4quz]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[4quz]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QUZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QUZ FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[4quz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Norovirus_cat/GIV.2/CU081210E/USA/2010 Norovirus cat/GIV.2/CU081210E/USA/2010]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QUZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QUZ FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.35&#8491;</td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4qv2|4qv2]], [[4qva|4qva]]</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4quz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4quz OCA], [http://pdbe.org/4quz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4quz RCSB], [http://www.ebi.ac.uk/pdbsum/4quz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4quz ProSAT]</span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4quz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4quz OCA], [https://pdbe.org/4quz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4quz RCSB], [https://www.ebi.ac.uk/pdbsum/4quz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4quz ProSAT]</span></td></tr>
</table>
</table>
-
<div style="background-color:#fffaf0;">
+
== Function ==
-
== Publication Abstract from PubMed ==
+
[https://www.uniprot.org/uniprot/H8YRY9_9CALI H8YRY9_9CALI]
-
Norovirus infects different animals, including humans, mice, dogs, and cats. Here, we show an X-ray crystal structure of a feline GIV.2 norovirus capsid-protruding (P) domain to 2.35A resolution. The feline GIV.2 P domain was reminiscent of human norovirus P domains, except for a novel P2 subdomain alpha-helix and an extended P1 subdomain interface loop. These new structural features likely obstructed histo-blood group antigens, which are attachment factors for human norovirus, from binding at the equivalent sites on the feline GIV.2 P domain. Additionally, an ELISA showed that the feline GIV.2 was antigenically distinct from a human GII.10 norovirus.
+
-
Structural analysis of a feline norovirus protruding domain.,Singh BK, Glatt S, Ferrer JL, Koromyslova AD, Leuthold MM, Dunder J, Hansman GS Virology. 2015 Jan 1;474:181-5. doi: 10.1016/j.virol.2014.10.028. Epub 2014 Nov, 19. PMID:25463616<ref>PMID:25463616</ref>
+
==See Also==
-
 
+
*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
-
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+
-
</div>
+
-
<div class="pdbe-citations 4quz" style="background-color:#fffaf0;"></div>
+
-
== References ==
+
-
<references/>
+
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Hansman, G S]]
+
[[Category: Large Structures]]
-
[[Category: Singh, B K]]
+
[[Category: Norovirus cat/GIV 2/CU081210E/USA/2010]]
-
[[Category: Feline norovirus]]
+
[[Category: Hansman GS]]
-
[[Category: P domain]]
+
[[Category: Singh BK]]
-
[[Category: Protruding domain]]
+
-
[[Category: Viral capsid protein]]
+
-
[[Category: Viral protein]]
+

Current revision

Crystal structure of Feline Norovirus P Domain

PDB ID 4quz

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4quz"
Personal tools