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4qv2

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==Unliganded crystal structure of Feline Norovirus P Domain co-crystallized with HBGA A-trisaccharide==
==Unliganded crystal structure of Feline Norovirus P Domain co-crystallized with HBGA A-trisaccharide==
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<StructureSection load='4qv2' size='340' side='right' caption='[[4qv2]], [[Resolution|resolution]] 1.68&Aring;' scene=''>
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<StructureSection load='4qv2' size='340' side='right'caption='[[4qv2]], [[Resolution|resolution]] 1.68&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4qv2]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QV2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QV2 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4qv2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Norovirus_cat/GIV.2/CU081210E/USA/2010 Norovirus cat/GIV.2/CU081210E/USA/2010]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QV2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QV2 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.68&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4quz|4quz]], [[4qva|4qva]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qv2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qv2 OCA], [http://pdbe.org/4qv2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4qv2 RCSB], [http://www.ebi.ac.uk/pdbsum/4qv2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4qv2 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qv2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qv2 OCA], [https://pdbe.org/4qv2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qv2 RCSB], [https://www.ebi.ac.uk/pdbsum/4qv2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qv2 ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/H8YRY9_9CALI H8YRY9_9CALI]
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Norovirus infects different animals, including humans, mice, dogs, and cats. Here, we show an X-ray crystal structure of a feline GIV.2 norovirus capsid-protruding (P) domain to 2.35A resolution. The feline GIV.2 P domain was reminiscent of human norovirus P domains, except for a novel P2 subdomain alpha-helix and an extended P1 subdomain interface loop. These new structural features likely obstructed histo-blood group antigens, which are attachment factors for human norovirus, from binding at the equivalent sites on the feline GIV.2 P domain. Additionally, an ELISA showed that the feline GIV.2 was antigenically distinct from a human GII.10 norovirus.
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Structural analysis of a feline norovirus protruding domain.,Singh BK, Glatt S, Ferrer JL, Koromyslova AD, Leuthold MM, Dunder J, Hansman GS Virology. 2015 Jan 1;474:181-5. doi: 10.1016/j.virol.2014.10.028. Epub 2014 Nov, 19. PMID:25463616<ref>PMID:25463616</ref>
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==See Also==
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*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 4qv2" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Hansman, G S]]
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[[Category: Large Structures]]
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[[Category: Singh, B K]]
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[[Category: Norovirus cat/GIV 2/CU081210E/USA/2010]]
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[[Category: Capsid protein]]
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[[Category: Hansman GS]]
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[[Category: Feline norovirus]]
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[[Category: Singh BK]]
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[[Category: P domain]]
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[[Category: Protruding domain]]
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[[Category: Viral protein]]
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Current revision

Unliganded crystal structure of Feline Norovirus P Domain co-crystallized with HBGA A-trisaccharide

PDB ID 4qv2

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