4xzf

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (09:03, 20 March 2024) (edit) (undo)
 
(5 intermediate revisions not shown.)
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 4xzf is ON HOLD until Paper Publication
+
==Crystal structure of HIRAN domain of human HLTF in complex with DNA==
-
 
+
<StructureSection load='4xzf' size='340' side='right'caption='[[4xzf]], [[Resolution|resolution]] 1.38&Aring;' scene=''>
-
Authors: Hishiki, A., Hashimoto, H.
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[4xzf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XZF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XZF FirstGlance]. <br>
-
Description:
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.38&#8491;</td></tr>
-
[[Category: Unreleased Structures]]
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xzf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xzf OCA], [https://pdbe.org/4xzf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xzf RCSB], [https://www.ebi.ac.uk/pdbsum/4xzf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xzf ProSAT]</span></td></tr>
-
[[Category: Hashimoto, H]]
+
</table>
-
[[Category: Hishiki, A]]
+
== Function ==
 +
[https://www.uniprot.org/uniprot/HLTF_HUMAN HLTF_HUMAN] Has both helicase and E3 ubiquitin ligase activities. Possesses intrinsic ATP-dependent nucleosome-remodeling activity; This activity may be required for transcriptional activation or repression of specific target promoters (By similarity). These may include the SERPINE1 and HIV-1 promoters and the SV40 enhancer, to which this protein can bind directly. Plays a role in error-free postreplication repair (PRR) of damaged DNA and maintains genomic stability through acting as a ubiquitin ligase for 'Lys-63'-linked polyubiquitination of chromatin-bound PCNA.<ref>PMID:10391891</ref> <ref>PMID:18316726</ref> <ref>PMID:18719106</ref> <ref>PMID:7876228</ref> <ref>PMID:8672239</ref> <ref>PMID:9126292</ref>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Homo sapiens]]
 +
[[Category: Large Structures]]
 +
[[Category: Synthetic construct]]
 +
[[Category: Hashimoto H]]
 +
[[Category: Hishiki A]]

Current revision

Crystal structure of HIRAN domain of human HLTF in complex with DNA

PDB ID 4xzf

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4xzf"
Personal tools