4yh2

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (09:03, 20 March 2024) (edit) (undo)
 
(2 intermediate revisions not shown.)
Line 3: Line 3:
<StructureSection load='4yh2' size='340' side='right'caption='[[4yh2]], [[Resolution|resolution]] 1.72&Aring;' scene=''>
<StructureSection load='4yh2' size='340' side='right'caption='[[4yh2]], [[Resolution|resolution]] 1.72&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[4yh2]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YH2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YH2 FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[4yh2]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YH2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YH2 FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.72&#8491;</td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">GstE6, CG17530, Dmel_CG17530 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene></td></tr>
-
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutathione_transferase Glutathione transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.18 2.5.1.18] </span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4yh2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yh2 OCA], [https://pdbe.org/4yh2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4yh2 RCSB], [https://www.ebi.ac.uk/pdbsum/4yh2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4yh2 ProSAT]</span></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yh2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yh2 OCA], [http://pdbe.org/4yh2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4yh2 RCSB], [http://www.ebi.ac.uk/pdbsum/4yh2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4yh2 ProSAT]</span></td></tr>
+
</table>
</table>
-
<div style="background-color:#fffaf0;">
+
== Function ==
-
== Publication Abstract from PubMed ==
+
[https://www.uniprot.org/uniprot/A1ZB71_DROME A1ZB71_DROME]
-
Epsilon class glutathione transferases (GSTs) have been shown to contribute significantly to insecticide resistance. We report a new Epsilon class protein crystal structure from Drosophila melanogaster for the glutathione transferase DmGSTE6. The structure reveals a novel Epsilon clasp motif that is conserved across hundreds of millions of years of evolution of the insect Diptera order. This histidine-serine motif lies in the subunit interface and appears to contribute to quaternary stability as well as directly connecting the two glutathiones in the active sites of this dimeric enzyme.
+
-
 
+
-
Epsilon glutathione transferases possess a unique class-conserved subunit interface motif that directly interacts with glutathione in the active site.,Wongsantichon J, Robinson RC, Ketterman AJ Biosci Rep. 2015 Oct 20;35(6). pii: e00272. doi: 10.1042/BSR20150183. PMID:26487708<ref>PMID:26487708</ref>
+
-
 
+
-
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+
-
</div>
+
-
<div class="pdbe-citations 4yh2" style="background-color:#fffaf0;"></div>
+
==See Also==
==See Also==
-
*[[Glutathione S-transferase|Glutathione S-transferase]]
+
*[[Glutathione S-transferase 3D structures|Glutathione S-transferase 3D structures]]
-
== References ==
+
-
<references/>
+
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Drome]]
+
[[Category: Drosophila melanogaster]]
-
[[Category: Glutathione transferase]]
+
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: Ketterman, A J]]
+
[[Category: Ketterman AJ]]
-
[[Category: Robinson, R C]]
+
[[Category: Robinson RC]]
-
[[Category: Wongsantichon, J]]
+
[[Category: Wongsantichon J]]
-
[[Category: Drosophila]]
+
-
[[Category: Transferase]]
+

Current revision

Glutathione Transferase E6 from Drosophila melanogaster

PDB ID 4yh2

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4yh2"
Personal tools