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5ayn
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 5ayn is ON HOLD Authors: Taniguchi, R., Kato, H.E., Font, J., Deshpande, C.N., Ishitani, R., Jormakka, M., Nureki, O. Description: Crystal structur...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of a bacterial homologue of iron transporter ferroportin in outward-facing state== | |
| - | + | <StructureSection load='5ayn' size='340' side='right'caption='[[5ayn]], [[Resolution|resolution]] 2.20Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5ayn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bdellovibrio_bacteriovorus_HD100 Bdellovibrio bacteriovorus HD100]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AYN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5AYN FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.202Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ayn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ayn OCA], [https://pdbe.org/5ayn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ayn RCSB], [https://www.ebi.ac.uk/pdbsum/5ayn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ayn ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Function == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/FPN_BDEBA FPN_BDEBA] Iron transpoter that exports Fe(2+) from the cell. Also binds to Co(2+) and Ni(2+). May act as a multivalent divalent metal transporter (PubMed:26608034). The transporter is composed of 12 transmembrane (TM) helices organized into N-terminal (TM1-6) and C-terminal (TM7-12) domains. The substrate-binding site is formed at the interface of the two domains and is alternately accessible from either side of the membrane. The transport cycle is viewed as a series of ligand-induced conformational changes that include open outward and open inward states (PubMed:26461048, PubMed:30082682).<ref>PMID:26461048</ref> <ref>PMID:26608034</ref> <ref>PMID:30082682</ref> |
| - | [[Category: | + | == References == |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| + | </StructureSection> | ||
| + | [[Category: Bdellovibrio bacteriovorus HD100]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Deshpande CN]] | ||
| + | [[Category: Font J]] | ||
| + | [[Category: Ishitani R]] | ||
| + | [[Category: Jormakka M]] | ||
| + | [[Category: Kato HE]] | ||
| + | [[Category: Nureki O]] | ||
| + | [[Category: Taniguchi R]] | ||
Current revision
Crystal structure of a bacterial homologue of iron transporter ferroportin in outward-facing state
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