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5b1z
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 5b1z is ON HOLD Authors: Yuan, Y.A. Description: Crystal structure of Bcl-xL in complex with HBx-BH3 motif Category: Unreleased Structures [[Ca...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of Bcl-xL in complex with HBx-BH3 motif== | |
| + | <StructureSection load='5b1z' size='340' side='right'caption='[[5b1z]], [[Resolution|resolution]] 2.15Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5b1z]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Hepatitis_B_virus Hepatitis B virus] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5B1Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5B1Z FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5b1z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5b1z OCA], [https://pdbe.org/5b1z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5b1z RCSB], [https://www.ebi.ac.uk/pdbsum/5b1z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5b1z ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/B2CL1_HUMAN B2CL1_HUMAN] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> Isoform Bcl-X(S) promotes apoptosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[B-cell lymphoma proteins 3D structures|B-cell lymphoma proteins 3D structures]] | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| - | [[Category: Yuan | + | __TOC__ |
| + | </StructureSection> | ||
| + | [[Category: Hepatitis B virus]] | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Yuan YA]] | ||
Current revision
Crystal structure of Bcl-xL in complex with HBx-BH3 motif
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