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5coi

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'''Unreleased structure'''
 
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The entry 5coi is ON HOLD
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==Crystal Structure of the first bromodomain of human BRD4 in complex with benzo[cd]indol-2(1H)-one ligand==
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<StructureSection load='5coi' size='340' side='right'caption='[[5coi]], [[Resolution|resolution]] 1.62&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5coi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5COI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5COI FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.62&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=55K:1-({[(1-ETHYL-2-OXO-1,2-DIHYDROBENZO[CD]INDOL-6-YL)SULFONYL]AMINO}METHYL)CYCLOPENTANECARBOXYLIC+ACID'>55K</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5coi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5coi OCA], [https://pdbe.org/5coi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5coi RCSB], [https://www.ebi.ac.uk/pdbsum/5coi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5coi ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
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Authors: Zhang, Y., Song, M., Liu, Z., Xue, X.
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==See Also==
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*[[Bromodomain-containing protein 3D structures|Bromodomain-containing protein 3D structures]]
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Description: Crystal Structure Analysis of the BRD4(1)
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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[[Category: Zhang, Y]]
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__TOC__
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[[Category: Liu, Z]]
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</StructureSection>
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[[Category: Song, M]]
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[[Category: Homo sapiens]]
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[[Category: Xue, X]]
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[[Category: Large Structures]]
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[[Category: Liu Z]]
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[[Category: Song M]]
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[[Category: Xu Y]]
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[[Category: Xue X]]
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[[Category: Zhang Y]]

Current revision

Crystal Structure of the first bromodomain of human BRD4 in complex with benzo[cd]indol-2(1H)-one ligand

PDB ID 5coi

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