5e1t

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'''Unreleased structure'''
 
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The entry 5e1t is ON HOLD
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==Crystal structure of TRAF1 TRAF domain==
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<StructureSection load='5e1t' size='340' side='right'caption='[[5e1t]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5e1t]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E1T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5E1T FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5e1t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e1t OCA], [https://pdbe.org/5e1t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5e1t RCSB], [https://www.ebi.ac.uk/pdbsum/5e1t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5e1t ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TRAF1_HUMAN TRAF1_HUMAN] Adapter molecule that regulates the activation of NF-kappa-B and JNK. Plays a role in the regulation of cell survival and apoptosis. The heterotrimer formed by TRAF1 and TRAF2 is part of a E3 ubiquitin-protein ligase complex that promotes ubiquitination of target proteins, such as MAP3K14. The TRAF1/TRAF2 complex recruits the antiapoptotic E3 protein-ubiquitin ligases BIRC2 and BIRC3 to TNFRSF1B/TNFR2.<ref>PMID:10692572</ref> <ref>PMID:16323247</ref> <ref>PMID:18429822</ref> <ref>PMID:19698991</ref> <ref>PMID:19287455</ref> <ref>PMID:20385093</ref>
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Authors: Park, H.H., Kim, C.M.
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==See Also==
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*[[TNF receptor-associated factor 3D structures|TNF receptor-associated factor 3D structures]]
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Description: Crystal structure of TRAF1 TRAF domain
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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[[Category: Park, H.H]]
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__TOC__
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[[Category: Kim, C.M]]
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Kim CM]]
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[[Category: Park HH]]

Current revision

Crystal structure of TRAF1 TRAF domain

PDB ID 5e1t

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OCA

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