This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
5eqj
From Proteopedia
(Difference between revisions)
m (Protected "5eqj" [edit=sysop:move=sysop]) |
|||
| (4 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the two-subunit tRNA m1A58 methyltransferase from Saccharomyces cerevisiae== | |
| + | <StructureSection load='5eqj' size='340' side='right'caption='[[5eqj]], [[Resolution|resolution]] 2.20Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5eqj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EQJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5EQJ FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5eqj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5eqj OCA], [https://pdbe.org/5eqj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5eqj RCSB], [https://www.ebi.ac.uk/pdbsum/5eqj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5eqj ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/TRM6_YEAST TRM6_YEAST] Substrate-binding subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA. Binds RNA. Also required for repression of GCN4 mRNA translation by the upstream open reading frames (uORFs) under conditions of amino acid sufficiency.<ref>PMID:10779558</ref> <ref>PMID:7542616</ref> <ref>PMID:9851972</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[TRNA methyltransferase 3D structures|TRNA methyltransferase 3D structures]] | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Saccharomyces cerevisiae S288C]] |
| - | [[Category: | + | [[Category: Fan X]] |
| - | [[Category: Wang | + | [[Category: Jiang X]] |
| - | [[Category: | + | [[Category: Li X]] |
| + | [[Category: Teng M]] | ||
| + | [[Category: Wang C]] | ||
| + | [[Category: Wang M]] | ||
| + | [[Category: Zhu Y]] | ||
Current revision
Crystal structure of the two-subunit tRNA m1A58 methyltransferase from Saccharomyces cerevisiae
| |||||||||||
Categories: Large Structures | Saccharomyces cerevisiae S288C | Fan X | Jiang X | Li X | Teng M | Wang C | Wang M | Zhu Y
