5gs6

<StructureSection load='5gs6' size='340' side='right' caption='[[5gs6]], [[Resolution|resolution]] 2.85&Aring;' scene=''>

<table><tr><td colspan='2'>[[5gs6]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GS6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5GS6 FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5gs6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gs6 OCA], [http://pdbe.org/5gs6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5gs6 RCSB], [http://www.ebi.ac.uk/pdbsum/5gs6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5gs6 ProSAT]</span></td></tr>

== Publication Abstract from PubMed ==

The association of Zika virus (ZIKV) infections with microcephaly and neurological diseases has highlighted an emerging public health concern. Here, we report the crystal structure of the full-length ZIKV nonstructural protein 1 (NS1), a major host-interaction molecule that functions in flaviviral replication, pathogenesis, and immune evasion. Of note, a long intertwined loop is observed in the wing domain of ZIKV NS1, and forms a hydrophobic "spike", which can contribute to cellular membrane association. For different flaviviruses, the amino acid sequences of the "spike" are variable but their common characteristic is either hydrophobic or positively charged, which is a beneficial feature for membrane binding. Comparative studies with West Nile and Dengue virus NS1 structures reveal conserved features, but diversified electrostatic characteristics on both inner and outer faces. Our results suggest different mechanisms of flavivirus pathogenesis and should be considered during the development of diagnostic tools.

 

Contribution of intertwined loop to membrane association revealed by Zika virus full-length NS1 structure.,Xu X, Song H, Qi J, Liu Y, Wang H, Su C, Shi Y, Gao GF EMBO J. 2016 Aug 30. pii: e201695290. PMID:27578809<ref>PMID:27578809</ref>

 

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

<div class="pdbe-citations 5gs6" style="background-color:#fffaf0;"></div>

[[Category: Gao, G F]]

[[Category: Viral protein]]