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5h11

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==Crystal structure of Zebrafish Sec10==
==Crystal structure of Zebrafish Sec10==
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<StructureSection load='5h11' size='340' side='right' caption='[[5h11]], [[Resolution|resolution]] 2.73&Aring;' scene=''>
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<StructureSection load='5h11' size='340' side='right'caption='[[5h11]], [[Resolution|resolution]] 2.73&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5h11]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5H11 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5H11 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5h11]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5H11 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5H11 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.732&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5h11 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5h11 OCA], [http://pdbe.org/5h11 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5h11 RCSB], [http://www.ebi.ac.uk/pdbsum/5h11 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5h11 ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5h11 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5h11 OCA], [https://pdbe.org/5h11 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5h11 RCSB], [https://www.ebi.ac.uk/pdbsum/5h11 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5h11 ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/B0BLY0_DANRE B0BLY0_DANRE]
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The exocyst complex is a heterooctameric protein complex composed of Sec3, Sec5, Sec6, Sec8, Sec10, Sec15, Exo70 and Exo84. This complex plays an essential role in trafficking secretory vesicles to the plasma membrane through its interaction with phosphatidylinositol 4,5-bisphosphate and small GTPases. To date, the near-full-length structural information of each subunit has been limited to Exo70, although the C-terminal half structures of Sec6, Sec15 and Exo84 and the structures of the small GTPase-binding domains of Sec3, Sec5 and Exo84 have been reported. Here, we report the crystal structure of the near-full-length zebrafish Sec10 (zSec10) at 2.73 A resolution. The structure of zSec10 consists of tandem antiparallel helix bundles that form a straight rod, like helical core regions of other exocyst subunits. This structure provides the first atomic details of Sec10, which may be useful for future functional and structural studies of this subunit and the exocyst complex.
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Crystal structure of Sec10, a subunit of the exocyst complex.,Chen J, Yamagata A, Kubota K, Sato Y, Goto-Ito S, Fukai S Sci Rep. 2017 Jan 18;7:40909. doi: 10.1038/srep40909. PMID:28098232<ref>PMID:28098232</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 5h11" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Chen, J]]
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[[Category: Danio rerio]]
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[[Category: Fukai, S]]
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[[Category: Large Structures]]
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[[Category: Yamagata, A]]
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[[Category: Chen J]]
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[[Category: Exocyst complex]]
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[[Category: Fukai S]]
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[[Category: Exocytosis]]
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[[Category: Yamagata A]]
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[[Category: Helical protein]]
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[[Category: Membrane traffic]]
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Current revision

Crystal structure of Zebrafish Sec10

PDB ID 5h11

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