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5h47
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 5h47 is ON HOLD until Paper Publication Authors: Kato, R., Nishikawa, Y., Makyio, H. Description: Crystal structure of AOL complexed with 2-MeSe-Fu...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of AOL complexed with 2-MeSe-Fuc== | |
| - | + | <StructureSection load='5h47' size='340' side='right'caption='[[5h47]], [[Resolution|resolution]] 2.30Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5h47]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Aspergillus_oryzae_RIB40 Aspergillus oryzae RIB40]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5H47 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5H47 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FSW:(2S,3S,4R,5S,6R)-6-METHOXY-2-METHYL-5-METHYLSELANYL-OXANE-3,4-DIOL'>FSW</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5h47 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5h47 OCA], [https://pdbe.org/5h47 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5h47 RCSB], [https://www.ebi.ac.uk/pdbsum/5h47 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5h47 ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Function == |
| + | [https://www.uniprot.org/uniprot/LECF_ASPOR LECF_ASPOR] Lectin that specifically binds to L-fucose and weakly reacts with mannose and N-acetyl-neuraminic acid (PubMed:12092808, PubMed:27318092, PubMed:28041800). Has strongest preference for the alpha-1,6-fucosylated chain (core fucose) on glycoproteins among alpha-1,2-, alpha-1,3-, alpha-1,4-, and alpha-1,6-fucosylated chains (PubMed:17383961, PubMed:19109923). Binds to fucose residues of IgE in mice and human, causing antigen-independent IgE-mediated mast cell activation and anaphylactoid reactions in mice and is possibly implicated in allergic response to Aspergillus oryzae in humans (PubMed:21790704). Induces secretion of pro-inflammatory cytokines IL6 and IL8 implicated in ocular diseases such as mycotic keratitis, probably through its interaction with host toll-like receptors TLR2 and TLR4, followed by up-regulation of pro-inflammatory cytokines (PubMed:28470344).<ref>PMID:12092808</ref> <ref>PMID:17383961</ref> <ref>PMID:19109923</ref> <ref>PMID:21790704</ref> <ref>PMID:27318092</ref> <ref>PMID:28041800</ref> <ref>PMID:28470344</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Aspergillus oryzae RIB40]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Kato R]] | ||
| + | [[Category: Makyio H]] | ||
| + | [[Category: Nishikawa Y]] | ||
Current revision
Crystal structure of AOL complexed with 2-MeSe-Fuc
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