This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


5hzy

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: '''Unreleased structure''' The entry 5hzy is ON HOLD Authors: Do Hoon Kwon, Leehyeon Kim, Byeong-Won Kim, Seung Beom Hong, Hyun Kyu Song Description: Crystal structure of the legionell...)
Current revision (09:16, 20 March 2024) (edit) (undo)
 
(7 intermediate revisions not shown.)
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 5hzy is ON HOLD
+
==Crystal structure of the legionella pneumophila effector protein RavZ - P6322==
-
 
+
<StructureSection load='5hzy' size='340' side='right'caption='[[5hzy]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
-
Authors: Do Hoon Kwon, Leehyeon Kim, Byeong-Won Kim, Seung Beom Hong, Hyun Kyu Song
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[5hzy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Legionella_pneumophila_subsp._pneumophila_str._Philadelphia_1 Legionella pneumophila subsp. pneumophila str. Philadelphia 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HZY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5HZY FirstGlance]. <br>
-
Description: Crystal structure of the legionella pneumophila effector protein RavZ -P6322
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.548&#8491;</td></tr>
-
[[Category: Unreleased Structures]]
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5hzy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hzy OCA], [https://pdbe.org/5hzy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5hzy RCSB], [https://www.ebi.ac.uk/pdbsum/5hzy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5hzy ProSAT]</span></td></tr>
-
[[Category: Do Hoon Kwon, Leehyeon Kim, Byeong-Won Kim, Seung Beom Hong, Hyun Kyu Song]]
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/RAVZ_LEGPH RAVZ_LEGPH] Cysteine protease effector that inhibits host cell autophagy by targeting lipid-conjugated ATG8 family proteins on pre-autophagosomal structures (PubMed:23112293, PubMed:29458288, PubMed:32686895, PubMed:31722778, PubMed:31719622, PubMed:33298241, PubMed:26343456, PubMed:28395732). Specifically hydrolyzes the amide bond between the C-terminal glycine residue and an adjacent aromatic residue in ATG8 proteins conjugated to phosphatidylethanolamine (PE), producing an ATG8 protein that cannot be reconjugated by host ATG7 and ATG3 (PubMed:23112293, PubMed:29458288, PubMed:32686895, PubMed:26343456, PubMed:28395732). Mechanistically, Ravz interacts with ATG8 proteins conjugated to PE via its LIR motifs, extracts them from the membrane of autophagosomes and integrates the PE part into its own lipid-binding site (PubMed:28395732). It then removes the lipid component of the ATG8 protein (PubMed:28395732). Also able to mediate delipidation of ATG8 proteins conjugated to phosphatidylserine (PS) during non-canonical autophagy (PubMed:33909989). Inhibits host ubiquitin recruitment to bacteria-containing vacuoles, suggesting that it is able to mediate delipidation of other proteins in addition to ATG8 proteins (PubMed:28971069). It is however not involved in the exclusion of autophagy adapters from bacteria-containing vacuoles decorated with ubiquitin (PubMed:32482642).<ref>PMID:23112293</ref> <ref>PMID:26343456</ref> <ref>PMID:28395732</ref> <ref>PMID:28971069</ref> <ref>PMID:29458288</ref> <ref>PMID:31719622</ref> <ref>PMID:31722778</ref> <ref>PMID:32482642</ref> <ref>PMID:32686895</ref> <ref>PMID:33298241</ref> <ref>PMID:33909989</ref>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Large Structures]]
 +
[[Category: Legionella pneumophila subsp. pneumophila str. Philadelphia 1]]
 +
[[Category: Hong SB]]
 +
[[Category: Kim B-W]]
 +
[[Category: Kim L]]
 +
[[Category: Kwon DH]]
 +
[[Category: Song HK]]

Current revision

Crystal structure of the legionella pneumophila effector protein RavZ - P6322

PDB ID 5hzy

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5hzy"
Personal tools